A Sense of Self: RIG-I's Tolerance to Host RNA

John W. Schoggins

doi:10.1016/j.immuni.2015.06.022

A Sense of Self: RIG-I's Tolerance to Host RNA

John W. Schoggins

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner etal. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.

Original language	English (US)
Pages (from-to)	1-2
Number of pages	2
Journal	Immunity
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2015.06.022
State	Published - Jul 21 2015

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2015.06.022

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title = "A Sense of Self: RIG-I's Tolerance to Host RNA",

abstract = "The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner etal. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.",

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AB - The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner etal. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.

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A Sense of Self: RIG-I's Tolerance to Host RNA

Abstract

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