A Sense of Self: RIG-I's Tolerance to Host RNA

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The innate immune sensor RIG-I recognizes viral RNA while avoiding unwanted activation by self RNA. In this issue of Immunity, Schuberth-Wagner etal. (2015) show that a histidine residue in the RNA binding pocket of RIG-I sterically excludes the cap1 structure of self RNA, thereby preventing downstream activation.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalImmunity
Volume43
Issue number1
DOIs
StatePublished - Jul 21 2015

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RNA
Viral RNA
Histidine
Immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

A Sense of Self : RIG-I's Tolerance to Host RNA. / Schoggins, John W.

In: Immunity, Vol. 43, No. 1, 21.07.2015, p. 1-2.

Research output: Contribution to journalArticle

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