A short biomimetic approach to the fully functionalized bicyclic framework of type A acylphloroglucinols

Elias A. Couladouros, Marianna Dakanali, Konstantinos D. Demadis, Veroniki P. Vidali

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29 Scopus citations


A biomimetic approach toward type A polyprenylated acylphlorogluclnols (PPAPs) Is described. The method Is based on a C-alkylation-cation cyclization reaction sequence, leading to a convenient buildup of molecular complexity, employing the simple and readily available deoxycohumulone and an appropriately functionalized hydroxy halide. Thus, a versatile construction of the fully functlonallzed bicyclic framework of type A PPAPs (5) was achieved.

Original languageEnglish (US)
Pages (from-to)4430-4433
Number of pages4
JournalOrganic Letters
Issue number19
StatePublished - Oct 1 2009


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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