(Chemical Equation Presented) A rapid and scalable synthesis of the carbocyclic core of the potent antiangiogenic natural products, the cortistatins, is presented starting from readily available (+)-estrone. Key steps include a regio- and stereoselective benzylic cyanation and a Demjanov rearrangement.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry