A short, scalable synthesis of the carbocyclic core of the anti-angiogenic cortistatins from (+)-estrone by B-ring expansion

László Kürti, Barbara Czakó, E. J. Corey

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

(Chemical Equation Presented) A rapid and scalable synthesis of the carbocyclic core of the potent antiangiogenic natural products, the cortistatins, is presented starting from readily available (+)-estrone. Key steps include a regio- and stereoselective benzylic cyanation and a Demjanov rearrangement.

Original languageEnglish (US)
Pages (from-to)5247-5250
Number of pages4
JournalOrganic Letters
Volume10
Issue number22
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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