A SILAC-based proteomics elicits the molecular interactome of alisertib (MLN8237) in human erythroleukemia K562 cells

Medicine & Life Sciences

• MLN 8237 100%
• Leukemia, Erythroblastic, Acute 73%
• K562 Cells 66%
• Proteomics 51%
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive 22%
• Autophagy 13%
• Aurora Kinase A 10%
• Isotope Labeling 10%
• Therapeutics 9%
• Apoptosis 8%
• G2 Phase 7%
• p38 Mitogen-Activated Protein Kinases 7%
• Hematologic Neoplasms 7%
• Phosphatidylinositol 3-Kinases 6%
• Cell Division 6%
• Mitochondria 5%
• Cell Cycle 5%
• Cell Culture Techniques 5%
• Cell Survival 5%
• Cell Death 5%
• Proteins 5%
• Amino Acids 4%
• Clinical Studies 4%
• Western Blotting 4%
• Cell Proliferation 4%
• Neoplasms 4%
• Growth 3%

Chemical Compounds

• Aurora 44%
• Western Blotting 35%
• Stable Isotope 30%
• Cell Death 30%
• Cell Viability 27%
• Protein 23%
• Pharmacological Metabolism 21%
• Molecule 19%
• Flow 18%
• Acid 9%