A simple method for the electrophilic cyanation of secondary amines

Chuo Chen, Chen Zhu, Ji Bao Xia

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with an amine nucleophile. This oxidative N-cyanation reaction allows for the preparation of disubstituted cyanamides from amines without using highly toxic cyanogen halides.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalOrganic Letters
Volume16
Issue number1
DOIs
StatePublished - Jan 3 2014

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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