A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremor

S. J. Frucht, W. C. Houghton, Y. Bordelon, P. E. Greene, E. D. Louis

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

The authors performed an open-label, rater-blinded, add-on study of sodium oxybate in 20 patients with ethanol-responsive myoclonus or essential tremor. Blinded ratings of videotaped examinations showed improvements in myoclonus at rest, stimulus-sensitive myoclonus, action myoclonus, functional performance, and postural and kinetic tremor. Tolerability was acceptable, and more than half of the patients chose to continue treatment after the trial. Double-blind placebo-controlled studies in these disorders are warranted.

Original languageEnglish (US)
Pages (from-to)1967-1970
Number of pages4
JournalNeurology
Volume65
Issue number12
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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