A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in down syndrome

Hoang H. Nguyen, Patrick Y. Jay

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
JournalJournal of Pediatrics
Volume165
Issue number1
DOIs
StatePublished - Jul 2014
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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