A snapshot of nature's favorite pump

Philip J. Thomas, John F. Hunt

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The 4.5 Å map of the MsbA protein, a putative lipid A transporter from Escherichia coli, provides the first detailed structural model for the transmembrane domain and cytoplasmic 'loops' of an ABC transporter and the geometric relationship of these regions to the ATP-binding cassette motor domain. Based on this structure, specific hypotheses for the mechanics of the pump can now be formulated and tested.

Original languageEnglish (US)
Pages (from-to)920-923
Number of pages4
JournalNature Structural Biology
Volume8
Issue number11
DOIs
StatePublished - 2001

Fingerprint

Lipid A
ATP-Binding Cassette Transporters
Structural Models
Mechanics
Escherichia coli
Adenosine Triphosphate
Pumps
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

A snapshot of nature's favorite pump. / Thomas, Philip J.; Hunt, John F.

In: Nature Structural Biology, Vol. 8, No. 11, 2001, p. 920-923.

Research output: Contribution to journalArticle

Thomas, Philip J. ; Hunt, John F. / A snapshot of nature's favorite pump. In: Nature Structural Biology. 2001 ; Vol. 8, No. 11. pp. 920-923.
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