A statistically robust variance-components approach for quantitative trait linkage analysis

J. Wang, R. Guerra, J. Cohen

Research output: Contribution to journalArticle

5 Scopus citations


Previously we showed that a statistically robust version of the sib-pair method greatly increased power to detect linkage in the presence of outliers. In this paper we report on M-estimation to accommodate outliers in the variance-components approach to linkage analysis developed by Amos. Simulations show that in the presence of outliers the robust variance-components approach provides substantially greater power, more precise estimation of heritabilities, and better false-positive rates than the original Gaussian based approach. In the absence of outliers the performance of the robust variance-components approach is similar to that of the Gaussian based approach. For illustration we apply the method to two well characterized lipoprotein systems.

Original languageEnglish (US)
Pages (from-to)249-262
Number of pages14
JournalAnnals of Human Genetics
Issue number3
StatePublished - May 1 1999


ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this