A strategy for founding a global lymphocyte proteinpaedia and gene catalogue

Ivan Lefkovits, John R. Kettman, Christopher Coleclough

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

In this article, Ivan Lefkovits, John Kettman and Christopher Coleclough describe a strategy for a comprehensive analysis of the genes active in lymphocytes. It allows direct access to the coding sequence of any gene, provided that the two-dimensional gel spot coordinate position is known. The authors have constructed representative lymphocyte cDNA libraries and partitioned them into many sectors, each containing a unique set of cDNA clones. Data from the analysis of natural lymphocyte protein is compiled into a 'proteinpaedia', which is matched to a gene catalogue comprising the partitioned recombinant phage collection.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalImmunology Today
Volume11
Issue numberC
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Immunology

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