A study of lymphoma of large granular lymphocytes with modern modalities: Report of two cases and review of the literature

T. Sun, P. Schulman, J. Kolitz, M. J. Susin Brody, P. Koduru, W. Muuse, S. Hombal, S. Teichberg, J. Broome

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Two cases of lymphoma of large granular lymphocytes are reported. The first case expressed natural killer (NK) cell, some T-cell (CD 2, CD 5, CD 8), and HLA-DR antigens, but was negative for other T-cell (CD 3, CD 4, CD 7), T-cell receptor (TCR), B-cell, and myeloid antigens. Germline configuration was demonstrated for TCR, and immunoglobulin heavy and light chain genes. The second case expressed NK cell, some T-cell (CD 3, CD 7, CD 8), and TCR antigens, but was negative for other T-cell (CD 4, CD 5), B-cell, myeloid, and HLA-DR antigens. Rearrangement of TCR α and β chains were detected. Thus, the findings of case 1 were consistent with true NK cell lineage and case 2 with NK-like T-cell lineage. Our report underscores the heterogeneity of this newly recognized lymphoma, which nevertheless carries a consistently poor prognosis and is probably more prevalent in the Asian population. This study also provides information concerning immunophenotypes of cellular infiltrates in internal organs and cytogenetic abnormalities in this lymphoma; neither has been reported frequently in the literature. The importance of detecting cytoplasmic granules in tissue imprints or electron micrographs for differentiating other T-cell lymphomas is emphasized, and the classification of large granular lymphoproliferative disorders is discussed.

Original languageEnglish (US)
Pages (from-to)135-145
Number of pages11
JournalAmerican Journal of Hematology
Volume40
Issue number2
DOIs
StatePublished - 1992

Fingerprint

T-Cell Antigen Receptor
Lymphoma
Natural Killer Cells
Lymphocytes
T-Lymphocytes
HLA-DR Antigens
Cell Lineage
Immunoglobulin Light Chain Genes
B-Lymphocytes
Immunoglobulin Heavy Chain Genes
Cytoplasmic Granules
Natural Killer T-Cells
Lymphoproliferative Disorders
T-Cell Lymphoma
Chromosome Aberrations
Electrons
Antigens
Population

Keywords

  • lymphoma genotyping
  • lymphoma phenotyping
  • natural killer cell lymphoma
  • Tγ-cell lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

A study of lymphoma of large granular lymphocytes with modern modalities : Report of two cases and review of the literature. / Sun, T.; Schulman, P.; Kolitz, J.; Susin Brody, M. J.; Koduru, P.; Muuse, W.; Hombal, S.; Teichberg, S.; Broome, J.

In: American Journal of Hematology, Vol. 40, No. 2, 1992, p. 135-145.

Research output: Contribution to journalArticle

Sun, T, Schulman, P, Kolitz, J, Susin Brody, MJ, Koduru, P, Muuse, W, Hombal, S, Teichberg, S & Broome, J 1992, 'A study of lymphoma of large granular lymphocytes with modern modalities: Report of two cases and review of the literature', American Journal of Hematology, vol. 40, no. 2, pp. 135-145. https://doi.org/10.1002/ajh.2830400211
Sun, T. ; Schulman, P. ; Kolitz, J. ; Susin Brody, M. J. ; Koduru, P. ; Muuse, W. ; Hombal, S. ; Teichberg, S. ; Broome, J. / A study of lymphoma of large granular lymphocytes with modern modalities : Report of two cases and review of the literature. In: American Journal of Hematology. 1992 ; Vol. 40, No. 2. pp. 135-145.
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