A study on the potential-dependence of proton block of sodium channels

G. N. Mozhayeva, A. P. Naumov, E. D. Nosyreva

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Ionic currents through sodium channels in nodal membranes were measured under voltage clamp conditions both at normal and at low (4.8-4.9) external solution pH. The measurements of so-called 'instantaneous' currents were used to distinguish between the proton blockage in open channels and the influence of low pH on channel gating processes. It is shown that the amount of the proton blockage in open channels decreases as membrane potential becomes more positive. This result suggests that at least one of the acid groups accessible from the outside is located within the conducting pore. The influence of the other group(s) on the degree of potential-dependence of proton blockage is discussed.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalBBA - Biomembranes
Volume775
Issue number3
DOIs
StatePublished - Sep 5 1984

Keywords

  • Na channel
  • Nerve membrane
  • Proton blockage
  • Voltage clamp

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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