A subclass of bHLH proteins required for cardiac morphogenesis

Deepak Srivastava, Peter Cserjesi, Eric N. Olson

Research output: Contribution to journalShort survey

430 Scopus citations

Abstract

Skeletal muscle development is controlled by a family of muscle-specific basic helix-loop-helix (bHLH) transcription factors. Two bHLH genes, dHAND and eHAND, have now been isolated that are expressed in the bilateral heart primordia and subsequently throughout the primitive tubular heart and its derivatives during chick and mouse embryogenesis. Incubation of stage 8 chick embryos with dHAND and eHAND antisense oligonucleotides revealed that either oligonucleotide alone had no effect on embryonic development, whereas together they arrested development at the looping heart tube stage. Thus, dHAND and eHAND may play redundant roles in the regulation of the morphogenetic events of vertebrate heart development.

Original languageEnglish (US)
Pages (from-to)1995-1999
Number of pages5
JournalScience
Volume270
Issue number5244
DOIs
StatePublished - Dec 22 1995

ASJC Scopus subject areas

  • General

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