A subsequent-memory effect in dorsolateral prefrontal cortex

Bart Rypma, Mark D'Esposito

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The importance of brain regions for long-term memory encoding has been examined by comparison of encoding-related neural activity on trials in which successful recollection subsequently occurred to the encoding-related activity on trials in which successful recollection did not occur. We applied similar analyses to event-related functional magnetic resonance imaging (fMRI) data to explore the relative roles of dorsolateral and ventrolateral prefrontal cortex (PFC) regions during specific components of a working-memory (WM) maintenance task. The results of this study indicated that increases in dorsolateral PFC activity during encoding was related to subsequent retrieval-success. These results lend support to the hypothesis that ventrolateral PFC mediates a limited-capacity WM buffer that supports rehearsal maintenance functions while dorsolateral PFC mediates WM organization functions that accommodate the capacity limits of WM maintenance.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalCognitive Brain Research
Volume16
Issue number2
DOIs
StatePublished - Apr 2003

Fingerprint

Prefrontal Cortex
Short-Term Memory
Maintenance
Long-Term Memory
Buffers
Magnetic Resonance Imaging
Brain

Keywords

  • Functional magnetic resonance imaging
  • Prefrontal cortex
  • Subsequent-memory effect
  • Working memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

A subsequent-memory effect in dorsolateral prefrontal cortex. / Rypma, Bart; D'Esposito, Mark.

In: Cognitive Brain Research, Vol. 16, No. 2, 04.2003, p. 162-166.

Research output: Contribution to journalArticle

Rypma, Bart ; D'Esposito, Mark. / A subsequent-memory effect in dorsolateral prefrontal cortex. In: Cognitive Brain Research. 2003 ; Vol. 16, No. 2. pp. 162-166.
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