A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity

Dorothea Zucker-Franklin, Zeenat F. Nabi, E. J. Corey, David R. Corey

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A synthetic aromatic sulfonate (I), which has been found to be an effective inhibitor of arylsulfatase, reduces NK-cell mediated cytotoxicity by ca. 60% at 10 μM concentration. At lower concentrations the effect is concentration dependent, but no further reduction of cytotoxicity is observed at concentrations above 10 μM.

Original languageEnglish (US)
Pages (from-to)540-543
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume126
Issue number1
DOIs
StatePublished - Jan 16 1985

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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