A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity

Dorothea Zucker-Franklin; Zeenat F. Nabi; E. J. Corey; David R. Corey

doi:10.1016/0006-291X(85)90639-4

A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity

Dorothea Zucker-Franklin, Zeenat F. Nabi, E. J. Corey, David R. Corey

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Abstract

A synthetic aromatic sulfonate (I), which has been found to be an effective inhibitor of arylsulfatase, reduces NK-cell mediated cytotoxicity by ca. 60% at 10 μM concentration. At lower concentrations the effect is concentration dependent, but no further reduction of cytotoxicity is observed at concentrations above 10 μM.

Original language	English (US)
Pages (from-to)	540-543
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	126
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(85)90639-4
State	Published - Jan 16 1985

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(85)90639-4

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title = "A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity",

abstract = "A synthetic aromatic sulfonate (I), which has been found to be an effective inhibitor of arylsulfatase, reduces NK-cell mediated cytotoxicity by ca. 60% at 10 μM concentration. At lower concentrations the effect is concentration dependent, but no further reduction of cytotoxicity is observed at concentrations above 10 μM.",

author = "Dorothea Zucker-Franklin and Nabi, {Zeenat F.} and Corey, {E. J.} and Corey, {David R.}",

note = "Funding Information: was assisted ftusncially by grants to NYU from the National Institutes and AM-12274) and a National Institutes of Health grant (General to Harvard Universtty.",

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T1 - A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity

AU - Zucker-Franklin, Dorothea

AU - Nabi, Zeenat F.

AU - Corey, E. J.

AU - Corey, David R.

N1 - Funding Information: was assisted ftusncially by grants to NYU from the National Institutes and AM-12274) and a National Institutes of Health grant (General to Harvard Universtty.

PY - 1985/1/16

Y1 - 1985/1/16

N2 - A synthetic aromatic sulfonate (I), which has been found to be an effective inhibitor of arylsulfatase, reduces NK-cell mediated cytotoxicity by ca. 60% at 10 μM concentration. At lower concentrations the effect is concentration dependent, but no further reduction of cytotoxicity is observed at concentrations above 10 μM.

AB - A synthetic aromatic sulfonate (I), which has been found to be an effective inhibitor of arylsulfatase, reduces NK-cell mediated cytotoxicity by ca. 60% at 10 μM concentration. At lower concentrations the effect is concentration dependent, but no further reduction of cytotoxicity is observed at concentrations above 10 μM.

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A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity

Abstract

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