A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity

Dorothea Zucker-Franklin, Zeenat F. Nabi, E. J. Corey, David R. Corey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A synthetic aromatic sulfonate (I), which has been found to be an effective inhibitor of arylsulfatase, reduces NK-cell mediated cytotoxicity by ca. 60% at 10 μM concentration. At lower concentrations the effect is concentration dependent, but no further reduction of cytotoxicity is observed at concentrations above 10 μM.

Original languageEnglish (US)
Pages (from-to)540-543
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume126
Issue number1
DOIs
StatePublished - Jan 16 1985

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Arylsulfatases
Cytotoxicity
Natural Killer Cells
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity. / Zucker-Franklin, Dorothea; Nabi, Zeenat F.; Corey, E. J.; Corey, David R.

In: Biochemical and Biophysical Research Communications, Vol. 126, No. 1, 16.01.1985, p. 540-543.

Research output: Contribution to journalArticle

Zucker-Franklin, Dorothea ; Nabi, Zeenat F. ; Corey, E. J. ; Corey, David R. / A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity. In: Biochemical and Biophysical Research Communications. 1985 ; Vol. 126, No. 1. pp. 540-543.
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