A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis

Ruth Ann Marrie, Nadia Reider, Jeffrey Cohen, Olaf Stuve, Per S. Sorensen, Gary Cutter, Stephen C. Reingold, Maria Trojano

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: As new therapies emerge which increase the risk of autoimmune disease it is increasingly important to understand the incidence of autoimmune disease in multiple sclerosis (MS). Objective: The purpose of this review is to estimate the incidence and prevalence of comorbid autoimmune disease in MS. Methods: The PUBMED, EMBASE, SCOPUS and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles were searched, and abstracts were independently screened by two reviewers. The data were abstracted by one reviewer using a standardized data collection form, and the findings were verified by a second reviewer. We assessed quality of the included studies using a standardized approach and conducted meta-analyses of population-based studies. Results: Sixty-one articles met the inclusion criteria. We observed substantial heterogeneity with respect to the populations studied, methods of ascertaining comorbidity, and reporting of findings. Based solely on population-based studies, the most prevalent autoimmune comorbidities were psoriasis (7.74%) and thyroid disease (6.44%). Our findings also suggest an increased risk of inflammatory bowel disease, likely uveitis and possibly pemphigoid. Conclusion: Fewer than half of the studies identified were of high quality. Population-based studies that report age, sex and ethnicity-specific estimates of incidence and prevalence are needed in jurisdictions worldwide.

Original languageEnglish (US)
Pages (from-to)282-293
Number of pages12
JournalMultiple Sclerosis
Volume21
Issue number3
DOIs
StatePublished - Mar 16 2015

Fingerprint

Autoimmune Diseases
Multiple Sclerosis
Incidence
Population
Comorbidity
Bullous Pemphigoid
Thyroid Diseases
Uveitis
Inflammatory Bowel Diseases
Psoriasis
Meta-Analysis
Databases
Therapeutics

Keywords

  • autoimmune disease
  • comorbidity
  • incidence
  • Multiple sclerosis
  • prevalence

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Marrie, R. A., Reider, N., Cohen, J., Stuve, O., Sorensen, P. S., Cutter, G., ... Trojano, M. (2015). A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis. Multiple Sclerosis, 21(3), 282-293. https://doi.org/10.1177/1352458514564490

A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis. / Marrie, Ruth Ann; Reider, Nadia; Cohen, Jeffrey; Stuve, Olaf; Sorensen, Per S.; Cutter, Gary; Reingold, Stephen C.; Trojano, Maria.

In: Multiple Sclerosis, Vol. 21, No. 3, 16.03.2015, p. 282-293.

Research output: Contribution to journalArticle

Marrie, RA, Reider, N, Cohen, J, Stuve, O, Sorensen, PS, Cutter, G, Reingold, SC & Trojano, M 2015, 'A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis', Multiple Sclerosis, vol. 21, no. 3, pp. 282-293. https://doi.org/10.1177/1352458514564490
Marrie, Ruth Ann ; Reider, Nadia ; Cohen, Jeffrey ; Stuve, Olaf ; Sorensen, Per S. ; Cutter, Gary ; Reingold, Stephen C. ; Trojano, Maria. / A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis. In: Multiple Sclerosis. 2015 ; Vol. 21, No. 3. pp. 282-293.
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