TY - JOUR
T1 - A systematic review of the neurocognitive effects of magnetic seizure therapy
AU - McClintock, Shawn M.
AU - Tirmizi, Owais
AU - Chansard, Matthieu
AU - Husain, Mustafa M.
N1 - Funding Information:
Declaration of interest: Shawn McClintock reports research grant support from the National Institutes of Health (NIH) grant number K23 MH087739, National Center for Research Resources (NCRR), and National Alliance for Research on Schizophrenia and Depression (NARSAD). Mustafa Husain reports research grant support from the NIH, the Stanley Foundation (grant number 05T-682), Cyberonics, Neuronetics, St Jude Medical and Magstim. The authors alone are responsible for the content and writing of the paper.
PY - 2011/10
Y1 - 2011/10
N2 - Magnetic seizure therapy (MST) is a novel neurotherapeutic intervention in development for the treatment of major affective disorders. Like other neurotherapeutic strategies such as electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS), a primary interest will be to monitor the associated neurocognitive effects. Thus, the purpose of this systematic review was to synthesize the available data on the neurocognitive effects of MST. The authors performed two independent literature searches with the following terms terms: MST, magnetic, magnetic seizure therapy, depression, neurocognition, cognitive, preclinical. We included in this review a total of eleven articles that mentioned MST and neurocognition in the abstract. The articles were divided into three methodological domains that included virtual computer simulations, preclinical studies, and clinical investigations. Collectively, the available evidence suggests MST has little to no adverse cognitive effects. Specifically, virtual computer simulations found the magnetic field was localized to grey matter, and preclinical studies found no neurocortical or neurocognitive sequelae. Clinical investigations found MST to be associated with rapid reorientation and intact anterograde and retrograde memory. Future investigations using translational methods are warranted to confirm these findings and to further determine the effects of MST on neurocognitive functions.
AB - Magnetic seizure therapy (MST) is a novel neurotherapeutic intervention in development for the treatment of major affective disorders. Like other neurotherapeutic strategies such as electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS), a primary interest will be to monitor the associated neurocognitive effects. Thus, the purpose of this systematic review was to synthesize the available data on the neurocognitive effects of MST. The authors performed two independent literature searches with the following terms terms: MST, magnetic, magnetic seizure therapy, depression, neurocognition, cognitive, preclinical. We included in this review a total of eleven articles that mentioned MST and neurocognition in the abstract. The articles were divided into three methodological domains that included virtual computer simulations, preclinical studies, and clinical investigations. Collectively, the available evidence suggests MST has little to no adverse cognitive effects. Specifically, virtual computer simulations found the magnetic field was localized to grey matter, and preclinical studies found no neurocortical or neurocognitive sequelae. Clinical investigations found MST to be associated with rapid reorientation and intact anterograde and retrograde memory. Future investigations using translational methods are warranted to confirm these findings and to further determine the effects of MST on neurocognitive functions.
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U2 - 10.3109/09540261.2011.623687
DO - 10.3109/09540261.2011.623687
M3 - Review article
C2 - 22200131
AN - SCOPUS:84855212727
SN - 0954-0261
VL - 23
SP - 413
EP - 423
JO - International Review of Psychiatry
JF - International Review of Psychiatry
IS - 5
ER -