A systematic review of the neurocognitive effects of magnetic seizure therapy

Shawn M. McClintock, Owais Tirmizi, Matthieu Chansard, Mustafa M. Husain

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Magnetic seizure therapy (MST) is a novel neurotherapeutic intervention in development for the treatment of major affective disorders. Like other neurotherapeutic strategies such as electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS), a primary interest will be to monitor the associated neurocognitive effects. Thus, the purpose of this systematic review was to synthesize the available data on the neurocognitive effects of MST. The authors performed two independent literature searches with the following terms terms: MST, magnetic, magnetic seizure therapy, depression, neurocognition, cognitive, preclinical. We included in this review a total of eleven articles that mentioned MST and neurocognition in the abstract. The articles were divided into three methodological domains that included virtual computer simulations, preclinical studies, and clinical investigations. Collectively, the available evidence suggests MST has little to no adverse cognitive effects. Specifically, virtual computer simulations found the magnetic field was localized to grey matter, and preclinical studies found no neurocortical or neurocognitive sequelae. Clinical investigations found MST to be associated with rapid reorientation and intact anterograde and retrograde memory. Future investigations using translational methods are warranted to confirm these findings and to further determine the effects of MST on neurocognitive functions.

Original languageEnglish (US)
Pages (from-to)413-423
Number of pages11
JournalInternational Review of Psychiatry
Volume23
Issue number5
DOIs
StatePublished - Oct 2011

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Seizures
Therapeutics
Computer Simulation
Electroconvulsive Therapy
Transcranial Magnetic Stimulation
Magnetic Fields
Mood Disorders
Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A systematic review of the neurocognitive effects of magnetic seizure therapy. / McClintock, Shawn M.; Tirmizi, Owais; Chansard, Matthieu; Husain, Mustafa M.

In: International Review of Psychiatry, Vol. 23, No. 5, 10.2011, p. 413-423.

Research output: Contribution to journalArticle

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