A tethering coherent protein in autophagosome maturation

Dandan Chen, Qing Zhong

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Autophagy is a cellular pathway that degrades damaged organelles, cytosol and microorganisms, thereby maintaining human health by preventing various diseases including cancers, neurodegenerative disorders and diabetes. In autophagy, autophagosomes carrying cellular cargoes fuse with lysosomes for degradation. The proper autophagosomelysosome fusion is pivotal for efficient autophagy activity. However, the molecular mechanism that specifically directs the fusion process is not clear. Our study reported that lysosome-localized TECPR1 (TECtonin β-Propeller Repeat containing 1) binds the autophagosomelocalized ATG12-ATG5 conjugate and recruits it to autolysosomes. TECPR1 also binds PtdIns3P in an ATG12-ATG5-dependent manner. Consequently, depletion of TECPR1 leads to a severe defect in autophagosome maturation. We propose that the interaction between TECPR1 and ATG12-ATG5 initiates the fusion between the autophagosome and lysosome, and TECPR1 is a TEthering Coherent PRotein in autophagosome maturation.

Original languageEnglish (US)
Pages (from-to)985-986
Number of pages2
JournalAutophagy
Volume8
Issue number6
DOIs
StatePublished - Jun 2012

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Keywords

  • ATG12-ATG5
  • Autophagosome maturation
  • Autophagy
  • TECPR1

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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