A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis

A. J. Ligocki, L. Lovato, D. Xiang, P. Guidry, R. H. Scheuermann, S. N. Willis, S. Almendinger, M. K. Racke, Elliot Frohman, D. A. Hafler, K. C. O'Connor, Nancy L Monson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

B cells isolated from the CSF of patients with multiple sclerosis (MS) have a unique accumulation of somatic hypermutation within the B cell receptor, termed the antibody gene signature (AGS). The focus of this study was to investigate whether the AGS could also be detected in MS brain tissue. Genetic analysis of B cells isolated from post-mortem CNS tissue samples from four MS brains demonstrated that signature enriched B cells are present at the site of tissue injury as well as in the circulating CSF.

Original languageEnglish (US)
Pages (from-to)192-193
Number of pages2
JournalJournal of Neuroimmunology
Volume226
Issue number1-2
DOIs
StatePublished - Sep 2010

Keywords

  • Antibody gene rearrangement
  • B lymphocytes
  • CNS tissue
  • Multiple sclerosis
  • Somatic hypermutation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Ligocki, A. J., Lovato, L., Xiang, D., Guidry, P., Scheuermann, R. H., Willis, S. N., Almendinger, S., Racke, M. K., Frohman, E., Hafler, D. A., O'Connor, K. C., & Monson, N. L. (2010). A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis. Journal of Neuroimmunology, 226(1-2), 192-193. https://doi.org/10.1016/j.jneuroim.2010.06.016