A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity [2]

Peter J. Brown, Deborah A. Winegar, Kelli D. Plunket, Linda B. Moore, Michael C. Lewis, Joan G. Wilson, Scott S. Sundseth, Cecilia S. Koble, Zhengdong Wu, James M. Chapman, Jürgen M. Lehmann, Steven A. Kliewer, Timothy M. Willson

Research output: Contribution to journalArticle

130 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)3785-3788
Number of pages4
JournalJournal of Medicinal Chemistry
Volume42
Issue number19
DOIs
StatePublished - Sep 23 1999

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Phenylurea Compounds
Fenofibrate
Hypolipidemic Agents
Butyrates
Zinc Fingers
DNA-Binding Proteins
Cytoplasmic and Nuclear Receptors
Nuclear Proteins
Lipid Metabolism
Sprague Dawley Rats
Transcription Factors
Lipids
Acids
GW 9578

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Brown, P. J., Winegar, D. A., Plunket, K. D., Moore, L. B., Lewis, M. C., Wilson, J. G., ... Willson, T. M. (1999). A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity [2]. Journal of Medicinal Chemistry, 42(19), 3785-3788. https://doi.org/10.1021/jm9903601

A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity [2]. / Brown, Peter J.; Winegar, Deborah A.; Plunket, Kelli D.; Moore, Linda B.; Lewis, Michael C.; Wilson, Joan G.; Sundseth, Scott S.; Koble, Cecilia S.; Wu, Zhengdong; Chapman, James M.; Lehmann, Jürgen M.; Kliewer, Steven A.; Willson, Timothy M.

In: Journal of Medicinal Chemistry, Vol. 42, No. 19, 23.09.1999, p. 3785-3788.

Research output: Contribution to journalArticle

Brown, PJ, Winegar, DA, Plunket, KD, Moore, LB, Lewis, MC, Wilson, JG, Sundseth, SS, Koble, CS, Wu, Z, Chapman, JM, Lehmann, JM, Kliewer, SA & Willson, TM 1999, 'A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity [2]', Journal of Medicinal Chemistry, vol. 42, no. 19, pp. 3785-3788. https://doi.org/10.1021/jm9903601
Brown, Peter J. ; Winegar, Deborah A. ; Plunket, Kelli D. ; Moore, Linda B. ; Lewis, Michael C. ; Wilson, Joan G. ; Sundseth, Scott S. ; Koble, Cecilia S. ; Wu, Zhengdong ; Chapman, James M. ; Lehmann, Jürgen M. ; Kliewer, Steven A. ; Willson, Timothy M. / A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity [2]. In: Journal of Medicinal Chemistry. 1999 ; Vol. 42, No. 19. pp. 3785-3788.
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