A widening perspective regarding the relationship between anti-epiligrin cicatricial pemphigoid and cancer

Elke Sadler; Zelmira Lazarova; Pichaya Sarasombath; Kim B. Yancey

doi:10.1016/j.jdermsci.2007.02.012

A widening perspective regarding the relationship between anti-epiligrin cicatricial pemphigoid and cancer

Elke Sadler, Zelmira Lazarova, Pichaya Sarasombath, Kim B. Yancey

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Anti-epiligrin cicatricial pemphigoid (AECP) is a chronic, autoimmune, subepidermal blistering disease characterized by circulating anti-basement membrane autoantibodies to laminin 5. Recent studies have shown that patients with this form of cicatricial pemphigoid have an increased relative risk for malignant solid tumors. The mechanism underlying this association of AECP and cancer is unknown, but there is accumulating evidence that laminin 5 plays a central role. In this article we report a patient with AECP and co-associated cutaneous T cell lymphoma and summarize all to date reported cases of AECP associated with malignancies. In addition we provide a review of the biology of laminin 5 and its potential role in cancer development.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Journal of Dermatological Science
Volume	47
Issue number	1
DOIs	https://doi.org/10.1016/j.jdermsci.2007.02.012
State	Published - Jul 1 2007

Keywords

Anti-epiligrin cicatricial pemphigoid (AECP)
Cancer
Laminin 5

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology

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10.1016/j.jdermsci.2007.02.012

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Cite this

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title = "A widening perspective regarding the relationship between anti-epiligrin cicatricial pemphigoid and cancer",

abstract = "Anti-epiligrin cicatricial pemphigoid (AECP) is a chronic, autoimmune, subepidermal blistering disease characterized by circulating anti-basement membrane autoantibodies to laminin 5. Recent studies have shown that patients with this form of cicatricial pemphigoid have an increased relative risk for malignant solid tumors. The mechanism underlying this association of AECP and cancer is unknown, but there is accumulating evidence that laminin 5 plays a central role. In this article we report a patient with AECP and co-associated cutaneous T cell lymphoma and summarize all to date reported cases of AECP associated with malignancies. In addition we provide a review of the biology of laminin 5 and its potential role in cancer development.",

keywords = "Anti-epiligrin cicatricial pemphigoid (AECP), Cancer, Laminin 5",

author = "Elke Sadler and Zelmira Lazarova and Pichaya Sarasombath and Yancey, {Kim B.}",

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AU - Sadler, Elke

AU - Lazarova, Zelmira

AU - Sarasombath, Pichaya

AU - Yancey, Kim B.

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N2 - Anti-epiligrin cicatricial pemphigoid (AECP) is a chronic, autoimmune, subepidermal blistering disease characterized by circulating anti-basement membrane autoantibodies to laminin 5. Recent studies have shown that patients with this form of cicatricial pemphigoid have an increased relative risk for malignant solid tumors. The mechanism underlying this association of AECP and cancer is unknown, but there is accumulating evidence that laminin 5 plays a central role. In this article we report a patient with AECP and co-associated cutaneous T cell lymphoma and summarize all to date reported cases of AECP associated with malignancies. In addition we provide a review of the biology of laminin 5 and its potential role in cancer development.

AB - Anti-epiligrin cicatricial pemphigoid (AECP) is a chronic, autoimmune, subepidermal blistering disease characterized by circulating anti-basement membrane autoantibodies to laminin 5. Recent studies have shown that patients with this form of cicatricial pemphigoid have an increased relative risk for malignant solid tumors. The mechanism underlying this association of AECP and cancer is unknown, but there is accumulating evidence that laminin 5 plays a central role. In this article we report a patient with AECP and co-associated cutaneous T cell lymphoma and summarize all to date reported cases of AECP associated with malignancies. In addition we provide a review of the biology of laminin 5 and its potential role in cancer development.

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