A widening perspective regarding the relationship between anti-epiligrin cicatricial pemphigoid and cancer

Elke Sadler, Zelmira Lazarova, Pichaya Sarasombath, Kim B. Yancey

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Anti-epiligrin cicatricial pemphigoid (AECP) is a chronic, autoimmune, subepidermal blistering disease characterized by circulating anti-basement membrane autoantibodies to laminin 5. Recent studies have shown that patients with this form of cicatricial pemphigoid have an increased relative risk for malignant solid tumors. The mechanism underlying this association of AECP and cancer is unknown, but there is accumulating evidence that laminin 5 plays a central role. In this article we report a patient with AECP and co-associated cutaneous T cell lymphoma and summarize all to date reported cases of AECP associated with malignancies. In addition we provide a review of the biology of laminin 5 and its potential role in cancer development.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Dermatological Science
Volume47
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Anti-epiligrin cicatricial pemphigoid (AECP)
  • Cancer
  • Laminin 5

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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