AAOA allergy primer: Immunodeficiency

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Background: Primary immunodeficiency is rare but should be considered in patients who present to the otolaryngologist with recurrent, severe, or treatment refractory infections. Methods: Recent literature and consensus statements on immunodeficiency were reviewed for clinically important information of relevance to otolaryngologists. Results: The most common and most relevant immunodeficiencies are humoral deficiencies with inadequate antibody production or an impairment in the production of specific antibody after antigen exposure. For otolaryngologists the most important immunodeficiencies include immunoglobulin A (IgA) deficiency, common variable immunodeficiency (CVID), and specific antibody deficiency. Simple screening tests can be used by the otolaryngologist to exclude the most common immunodeficiencies. The general treatment approach to patients with these immunodeficiencies includes airway hygiene, early and aggressive treatment of infections, immunization, and antibody replacement therapy. Conclusion: By virtue of their scope of practice, otolaryngologists are in a position to recognize and initiate the diagnostic workup of patients with immunodeficiency. Patients with a diagnosed primary immunodeficiency are best managed in a multidisciplinary manner with close cooperation among the otolaryngologist, immunologist, and other specialists that are involved in treating these multisystem diseases.

Original languageEnglish (US)
Pages (from-to)S74-S78
JournalInternational Forum of Allergy and Rhinology
Volume4
Issue numberSUPPL.2
DOIs
StatePublished - Sep 2014

Keywords

  • Antibody deficiency
  • Humoral immunodeficiency
  • Primary immunodeficiency
  • Rhinosinusitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

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