AAV-Mediated Artificial miRNA Reduces Pathogenic Polyglucosan Bodies and Neuroinflammation in Adult Polyglucosan Body and Lafora Disease Mouse Models

Medicine & Life Sciences

• Adult Form Polyglucosan Body Disease 100%
• polyglucosan 77%
• Dependovirus 63%
• Lafora Disease 56%
• MicroRNAs 43%
• Glycogen 35%
• Glycogen Synthase 23%
• 1,4-alpha-Glucan Branching Enzyme 14%
• Progressive Myoclonic Epilepsy 12%
• Glycogen Storage Disease 12%
• Glucans 11%
• Premature Mortality 10%
• Inclusion Bodies 9%
• Loss of Function Mutation 9%
• Enzymes 9%
• Motor Neurons 8%
• RNA Interference 8%
• Nervous System Diseases 8%
• Astrocytes 7%
• Genes 6%
• Down-Regulation 6%
• Pathology 5%
• Neurons 5%
• Messenger RNA 4%
• Mutation 4%
• Growth 4%
• Brain 4%
• Therapeutics 1%