ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse

Chonglun Xie, Stephen D. Turley, John M. Dietschy

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

This study uses the mouse to explore the role of ABCA1 in the movement of this cholesterol from the peripheral organs to the endocrine glands for hormone synthesis and liver for excretion. The sterol pool in all peripheral organs was constant and equaled 2,218 and 2,269 mg/kg, respectively, in abca+/+ and abca1-/- mice. Flux of cholesterol from these tissues equaled the rate of synthesis plus the rate of LDL-cholesterol uptake and was 49.9 mg/day/kg in control animals and 62.0 mg/day/kg in abca1-/- mice. In the abca+/+ animals, this amount of cholesterol moved from HDL into the liver for excretion. In the abca1-/- mice, the cholesterol from the periphery also reached the liver but did not use HDL. Fecal excretion of cholesterol was just as high in abac1-/- mice (198 mg/day/kg) as in the abac1+/+ animals (163 mg/day/kg), although the abac1-/- mice excreted relatively more neutral than acidic sterols. This study established that ABCA1 plays essentially no role in the turnover of cholesterol in peripheral organs or in the centripetal movement of this sterol to the endocrine glands, liver, and intestinal tract for excretion.

Original languageEnglish (US)
Pages (from-to)1316-1329
Number of pages14
JournalJournal of lipid research
Volume50
Issue number7
DOIs
StatePublished - Jul 2009

Keywords

  • ATP binding cassette transporter A1
  • Cholesterol absorption
  • Cholesterol synthesis
  • High density lipoprotein transport
  • Low density lipoprotein transport
  • Reverse cholesterol transport
  • Steroid hormones
  • Tangier disease

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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