Abdominal aortic aneurysms and malignant neoplasia: Double jeopardy

R. J. Valentine, A. S. Pearson, D. D. McIntire, R. T. Hagino, R. H. Turnage, G. P. Clagett

Research output: Contribution to journalArticle

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Abstract

Background. This study was performed to determine whether there is a significant association between abdominal aortic aneurysms (AAAs) and malignancy and to determine the impact of malignancy on late survival in patients with AAA. Methods. We studied 126 men undergoing AAA repair and compared them with 99 men undergoing aortofemoral bypass (AFB) for occlusive disease and with 100 men undergoing herniorrhaphy during the same period. Results. Fifty-one (40%) patients with AAA, 23 (23%) patients undergoing AFB, and 21 (21%) patients undergoing herniorrhaphy were diagnosed with cancer (p = 0.002). By life table analysis the proportion of subjects remaining cancer free at 5 years was 0.60 ± 0.05 for AAA, 0.83 ± 0.04 for AFB, and 0.81 ± 0.04 for herniorrhaphy (p = 0.004). Multivariate analysis selected four independent risk factors for cancer: presence of AAA (p = 0.003, odds ratio 1.4, confidence interval [CI] 1.2 to 1.7), age (p = 0.001, odds ratio per year 1.1, CI 1.0 to 1.1), smoking (p = 0.04, odds ratio 1.5, CI 1.0 to 2.2), and hypertension (p = 0.04, odds ratio 0.73, CI 0.5 to 1.0). Cancer deaths accounted for 32 % of late deaths in patients with AAA, which was not different compared with 26% of late deaths in patients undergoing AFB and 36% of late deaths in patients undergoing herniorrhaphy. Five-year cancer-free survival was 0.44 ± 0.05 for patients with AAA, 0.64 ± 0.05 for patients undergoing AFB, and 0.70 ± 0.05 for patients undergoing herniorrhaphy (p < 0.001, AAA versus herniorrhaphy only). Conclusions. Cancer is more prevalent in men with AAA than in men undergoing AFB or herniorrhaphy. The presence of AAA appears to be an independent risk factor for cancer. Despite the higher cancer prevalence in patients with AAA, cardiovascular disease accounted for the largest number of late deaths in this series, minimizing differences in cancer-free survival between patients with AAA and patients undergoing AFB.

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalSurgery
Volume123
Issue number2
DOIs
StatePublished - 1998

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Abdominal Aortic Aneurysm
Herniorrhaphy
Neoplasms
Odds Ratio
Confidence Intervals
Survival
Life Tables
Cardiovascular Diseases
Multivariate Analysis
Smoking

ASJC Scopus subject areas

  • Surgery

Cite this

Valentine, R. J., Pearson, A. S., McIntire, D. D., Hagino, R. T., Turnage, R. H., & Clagett, G. P. (1998). Abdominal aortic aneurysms and malignant neoplasia: Double jeopardy. Surgery, 123(2), 228-233. https://doi.org/10.1016/S0039-6060(98)70262-4

Abdominal aortic aneurysms and malignant neoplasia : Double jeopardy. / Valentine, R. J.; Pearson, A. S.; McIntire, D. D.; Hagino, R. T.; Turnage, R. H.; Clagett, G. P.

In: Surgery, Vol. 123, No. 2, 1998, p. 228-233.

Research output: Contribution to journalArticle

Valentine, RJ, Pearson, AS, McIntire, DD, Hagino, RT, Turnage, RH & Clagett, GP 1998, 'Abdominal aortic aneurysms and malignant neoplasia: Double jeopardy', Surgery, vol. 123, no. 2, pp. 228-233. https://doi.org/10.1016/S0039-6060(98)70262-4
Valentine, R. J. ; Pearson, A. S. ; McIntire, D. D. ; Hagino, R. T. ; Turnage, R. H. ; Clagett, G. P. / Abdominal aortic aneurysms and malignant neoplasia : Double jeopardy. In: Surgery. 1998 ; Vol. 123, No. 2. pp. 228-233.
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title = "Abdominal aortic aneurysms and malignant neoplasia: Double jeopardy",
abstract = "Background. This study was performed to determine whether there is a significant association between abdominal aortic aneurysms (AAAs) and malignancy and to determine the impact of malignancy on late survival in patients with AAA. Methods. We studied 126 men undergoing AAA repair and compared them with 99 men undergoing aortofemoral bypass (AFB) for occlusive disease and with 100 men undergoing herniorrhaphy during the same period. Results. Fifty-one (40{\%}) patients with AAA, 23 (23{\%}) patients undergoing AFB, and 21 (21{\%}) patients undergoing herniorrhaphy were diagnosed with cancer (p = 0.002). By life table analysis the proportion of subjects remaining cancer free at 5 years was 0.60 ± 0.05 for AAA, 0.83 ± 0.04 for AFB, and 0.81 ± 0.04 for herniorrhaphy (p = 0.004). Multivariate analysis selected four independent risk factors for cancer: presence of AAA (p = 0.003, odds ratio 1.4, confidence interval [CI] 1.2 to 1.7), age (p = 0.001, odds ratio per year 1.1, CI 1.0 to 1.1), smoking (p = 0.04, odds ratio 1.5, CI 1.0 to 2.2), and hypertension (p = 0.04, odds ratio 0.73, CI 0.5 to 1.0). Cancer deaths accounted for 32 {\%} of late deaths in patients with AAA, which was not different compared with 26{\%} of late deaths in patients undergoing AFB and 36{\%} of late deaths in patients undergoing herniorrhaphy. Five-year cancer-free survival was 0.44 ± 0.05 for patients with AAA, 0.64 ± 0.05 for patients undergoing AFB, and 0.70 ± 0.05 for patients undergoing herniorrhaphy (p < 0.001, AAA versus herniorrhaphy only). Conclusions. Cancer is more prevalent in men with AAA than in men undergoing AFB or herniorrhaphy. The presence of AAA appears to be an independent risk factor for cancer. Despite the higher cancer prevalence in patients with AAA, cardiovascular disease accounted for the largest number of late deaths in this series, minimizing differences in cancer-free survival between patients with AAA and patients undergoing AFB.",
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T1 - Abdominal aortic aneurysms and malignant neoplasia

T2 - Double jeopardy

AU - Valentine, R. J.

AU - Pearson, A. S.

AU - McIntire, D. D.

AU - Hagino, R. T.

AU - Turnage, R. H.

AU - Clagett, G. P.

PY - 1998

Y1 - 1998

N2 - Background. This study was performed to determine whether there is a significant association between abdominal aortic aneurysms (AAAs) and malignancy and to determine the impact of malignancy on late survival in patients with AAA. Methods. We studied 126 men undergoing AAA repair and compared them with 99 men undergoing aortofemoral bypass (AFB) for occlusive disease and with 100 men undergoing herniorrhaphy during the same period. Results. Fifty-one (40%) patients with AAA, 23 (23%) patients undergoing AFB, and 21 (21%) patients undergoing herniorrhaphy were diagnosed with cancer (p = 0.002). By life table analysis the proportion of subjects remaining cancer free at 5 years was 0.60 ± 0.05 for AAA, 0.83 ± 0.04 for AFB, and 0.81 ± 0.04 for herniorrhaphy (p = 0.004). Multivariate analysis selected four independent risk factors for cancer: presence of AAA (p = 0.003, odds ratio 1.4, confidence interval [CI] 1.2 to 1.7), age (p = 0.001, odds ratio per year 1.1, CI 1.0 to 1.1), smoking (p = 0.04, odds ratio 1.5, CI 1.0 to 2.2), and hypertension (p = 0.04, odds ratio 0.73, CI 0.5 to 1.0). Cancer deaths accounted for 32 % of late deaths in patients with AAA, which was not different compared with 26% of late deaths in patients undergoing AFB and 36% of late deaths in patients undergoing herniorrhaphy. Five-year cancer-free survival was 0.44 ± 0.05 for patients with AAA, 0.64 ± 0.05 for patients undergoing AFB, and 0.70 ± 0.05 for patients undergoing herniorrhaphy (p < 0.001, AAA versus herniorrhaphy only). Conclusions. Cancer is more prevalent in men with AAA than in men undergoing AFB or herniorrhaphy. The presence of AAA appears to be an independent risk factor for cancer. Despite the higher cancer prevalence in patients with AAA, cardiovascular disease accounted for the largest number of late deaths in this series, minimizing differences in cancer-free survival between patients with AAA and patients undergoing AFB.

AB - Background. This study was performed to determine whether there is a significant association between abdominal aortic aneurysms (AAAs) and malignancy and to determine the impact of malignancy on late survival in patients with AAA. Methods. We studied 126 men undergoing AAA repair and compared them with 99 men undergoing aortofemoral bypass (AFB) for occlusive disease and with 100 men undergoing herniorrhaphy during the same period. Results. Fifty-one (40%) patients with AAA, 23 (23%) patients undergoing AFB, and 21 (21%) patients undergoing herniorrhaphy were diagnosed with cancer (p = 0.002). By life table analysis the proportion of subjects remaining cancer free at 5 years was 0.60 ± 0.05 for AAA, 0.83 ± 0.04 for AFB, and 0.81 ± 0.04 for herniorrhaphy (p = 0.004). Multivariate analysis selected four independent risk factors for cancer: presence of AAA (p = 0.003, odds ratio 1.4, confidence interval [CI] 1.2 to 1.7), age (p = 0.001, odds ratio per year 1.1, CI 1.0 to 1.1), smoking (p = 0.04, odds ratio 1.5, CI 1.0 to 2.2), and hypertension (p = 0.04, odds ratio 0.73, CI 0.5 to 1.0). Cancer deaths accounted for 32 % of late deaths in patients with AAA, which was not different compared with 26% of late deaths in patients undergoing AFB and 36% of late deaths in patients undergoing herniorrhaphy. Five-year cancer-free survival was 0.44 ± 0.05 for patients with AAA, 0.64 ± 0.05 for patients undergoing AFB, and 0.70 ± 0.05 for patients undergoing herniorrhaphy (p < 0.001, AAA versus herniorrhaphy only). Conclusions. Cancer is more prevalent in men with AAA than in men undergoing AFB or herniorrhaphy. The presence of AAA appears to be an independent risk factor for cancer. Despite the higher cancer prevalence in patients with AAA, cardiovascular disease accounted for the largest number of late deaths in this series, minimizing differences in cancer-free survival between patients with AAA and patients undergoing AFB.

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