Abdominal wall defects and congenital heart disease

C. Gibbin, S. Touch, R. E. Broth, V. Berghella

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objectives: To determine the incidence of cardiac disease associated with abdominal wall defects of fetuses and associated parameters including maternal age, sex, gestational age at delivery, outcome, karyotypes, Apgar scores and associated congenital anomalies. Methods: This was a retrospective study of fetuses with a prenatal diagnosis of gastroschisis or omphalocele. The Maternal-Fetal Medicine Fetal Therapy (MFM) database was reviewed for all fetuses with abdominal wall defects identified prenatally. All available MFM records, fetal echocardiograms, neonatal echocardiograms and neonatal charts were reviewed for the types of abdominal wall defects and associated cardiac disease identified by ultrasound. Other parameters reviewed included: maternal age, sex, gestational age at delivery, outcome, karyotypes (when available), Apgar scores and associated congenital abnormalities. Results: Forty-eight fetuses with an abdominal wall defect and cardiac disease findings were identified. Of these fetuses 26 had gastroschisis and 22 had omphalocele. The mean maternal age was 24.0 ± 5.40 years in the gastroschisis and 29.2 ± 7.23 years in the omphalocele group (P < 0.01). Differences in mean gestational age at delivery, mean birth weight and median Apgar scores at 1 and 5 min were not statistically significant. Abnormal cardiac findings were seen in 4/26 (15%) cases of gastroschisis and included one case of peripheral pulmonary stenosis, two cases of supraventricular tachycardia and one case of persistent pulmonary hypertension (PPHN) of the newborn. Abnormal cardiac findings were seen in 10/22 (45%) cases of omphalocele and included one muscular ventricular septal defect, two atrial septal defects of the secundum variety, one ectopia cordis, one coarctation of the aorta, one dysplasia of the tricuspid valve, one large pericardial effusion and four cases of PPHN. Conclusions: Fetuses with omphalocele appear to have an increased risk not only of congenital heart disease (CHD) but also of perinatal cardiac abnormalities, especially PPHN. A prenatal maternal hyperoxia test may be of predictive value in determining which patients may develop PPHN. The fact that both CHD and PPHN are increased in fetuses with abdominal wall defects may be of value in counseling parents prenatally, and stresses the importance of performing echocardiography both prenatally and postnatally in these cases.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalUltrasound in Obstetrics and Gynecology
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2003

Fingerprint

heart diseases
fetuses
Abdominal Wall
hypertension
Umbilical Hernia
Heart Diseases
Fetus
Gastroschisis
Pulmonary Hypertension
defects
Apgar Score
Maternal Age
Gestational Age
delivery
magnetic force microscopy
abnormalities
Karyotype
hyperoxia
Ectopia Cordis
congenital anomalies

Keywords

  • Abdominal wall defects
  • Congenital heart defects
  • Fetal echocardiography
  • Fetus
  • Ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Acoustics and Ultrasonics

Cite this

Gibbin, C., Touch, S., Broth, R. E., & Berghella, V. (2003). Abdominal wall defects and congenital heart disease. Ultrasound in Obstetrics and Gynecology, 21(4), 334-337. https://doi.org/10.1002/uog.93

Abdominal wall defects and congenital heart disease. / Gibbin, C.; Touch, S.; Broth, R. E.; Berghella, V.

In: Ultrasound in Obstetrics and Gynecology, Vol. 21, No. 4, 01.04.2003, p. 334-337.

Research output: Contribution to journalArticle

Gibbin, C, Touch, S, Broth, RE & Berghella, V 2003, 'Abdominal wall defects and congenital heart disease', Ultrasound in Obstetrics and Gynecology, vol. 21, no. 4, pp. 334-337. https://doi.org/10.1002/uog.93
Gibbin, C. ; Touch, S. ; Broth, R. E. ; Berghella, V. / Abdominal wall defects and congenital heart disease. In: Ultrasound in Obstetrics and Gynecology. 2003 ; Vol. 21, No. 4. pp. 334-337.
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abstract = "Objectives: To determine the incidence of cardiac disease associated with abdominal wall defects of fetuses and associated parameters including maternal age, sex, gestational age at delivery, outcome, karyotypes, Apgar scores and associated congenital anomalies. Methods: This was a retrospective study of fetuses with a prenatal diagnosis of gastroschisis or omphalocele. The Maternal-Fetal Medicine Fetal Therapy (MFM) database was reviewed for all fetuses with abdominal wall defects identified prenatally. All available MFM records, fetal echocardiograms, neonatal echocardiograms and neonatal charts were reviewed for the types of abdominal wall defects and associated cardiac disease identified by ultrasound. Other parameters reviewed included: maternal age, sex, gestational age at delivery, outcome, karyotypes (when available), Apgar scores and associated congenital abnormalities. Results: Forty-eight fetuses with an abdominal wall defect and cardiac disease findings were identified. Of these fetuses 26 had gastroschisis and 22 had omphalocele. The mean maternal age was 24.0 ± 5.40 years in the gastroschisis and 29.2 ± 7.23 years in the omphalocele group (P < 0.01). Differences in mean gestational age at delivery, mean birth weight and median Apgar scores at 1 and 5 min were not statistically significant. Abnormal cardiac findings were seen in 4/26 (15{\%}) cases of gastroschisis and included one case of peripheral pulmonary stenosis, two cases of supraventricular tachycardia and one case of persistent pulmonary hypertension (PPHN) of the newborn. Abnormal cardiac findings were seen in 10/22 (45{\%}) cases of omphalocele and included one muscular ventricular septal defect, two atrial septal defects of the secundum variety, one ectopia cordis, one coarctation of the aorta, one dysplasia of the tricuspid valve, one large pericardial effusion and four cases of PPHN. Conclusions: Fetuses with omphalocele appear to have an increased risk not only of congenital heart disease (CHD) but also of perinatal cardiac abnormalities, especially PPHN. A prenatal maternal hyperoxia test may be of predictive value in determining which patients may develop PPHN. The fact that both CHD and PPHN are increased in fetuses with abdominal wall defects may be of value in counseling parents prenatally, and stresses the importance of performing echocardiography both prenatally and postnatally in these cases.",
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