Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity

Eva Marie Yang Moresco, Alfred J. Scheetz, William G. Bornmann, Anthony J. Koleske, Reiko Maki Fitzsimonds

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Abl family nonreceptor tyrosine kinases regulate cell morphogenesis through functional interactions with the actin cytoskeleton. The vertebrate Abl family kinases, Abl and Arg, are expressed in the adult mouse brain, where they may regulate actin cytoskeletal dynamics in mature neurons. Using immunoelectron microscopy, we have localized Abl and Arg to the pre- and postsynaptic compartments of synapses in the mouse hippocampal area CA1. Paired-pulse facilitation (PPF) was significantly reduced at the Schaffer collateral-CA1 (SC-CA1) excitatory synapses in hippocampal slices from abl-/- and arg-/- mice as compared with wild-type mice. Furthermore, treatment of wild-type slices with the specific Abl family kinase inhibitor STI571 also reduced PPF. Basal synaptic transmission, posttetanic potentiation (PTP), long-term potentiation (LTP), and long-term depression (LTD) were similar to wild-type controls in abl-/- and arg-/- slices and in STI571treated wild-type slices. These results indicate that an important function of Abl and Arg is to modulate synaptic efficacy via a presynaptic mechanism during repetitive activation.

Original languageEnglish (US)
Pages (from-to)1678-1687
Number of pages10
JournalJournal of neurophysiology
Volume89
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

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Neuronal Plasticity
Protein-Tyrosine Kinases
Synapses
Phosphotransferases
Immunoelectron Microscopy
Long-Term Potentiation
Actin Cytoskeleton
Morphogenesis
Synaptic Transmission
Vertebrates
Actins
Hippocampus
Neurons
Brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity. / Moresco, Eva Marie Yang; Scheetz, Alfred J.; Bornmann, William G.; Koleske, Anthony J.; Fitzsimonds, Reiko Maki.

In: Journal of neurophysiology, Vol. 89, No. 3, 01.03.2003, p. 1678-1687.

Research output: Contribution to journalArticle

Moresco, Eva Marie Yang ; Scheetz, Alfred J. ; Bornmann, William G. ; Koleske, Anthony J. ; Fitzsimonds, Reiko Maki. / Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity. In: Journal of neurophysiology. 2003 ; Vol. 89, No. 3. pp. 1678-1687.
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