Abnormal Brain Lateralization in High-Functioning Autism

Paul R. Escalante-Mead, Nancy J. Minshew, John A. Sweeney

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Disturbances in lateral preference in autism are of interest because of their potential to shed light on brain maturational processes in this disorder. Forty-seven autistic individuals with a history of disordered early language development and 22 autistic individuals with normal early language acquisition were matched with 112 healthy individuals and compared on a standardized measure of lateral preference, the Edinburgh Handedness Inventory. Autistic individuals with a history of early language disturbance showed more atypical cerebral dominance than both healthy participants and autistic individuals with normal early language skills. The data indicated maturational disturbances in establishing lateral preference rather than increased rates of left handedness. Atypical establishment of cerebral dominance may be one cause of disordered language development in autism.

Original languageEnglish (US)
Pages (from-to)539-543
Number of pages5
JournalJournal of Autism and Developmental Disorders
Volume33
Issue number5
DOIs
StatePublished - Oct 2003

Fingerprint

Autistic Disorder
Cerebral Dominance
Language Development
Functional Laterality
Language
Brain
Healthy Volunteers
Equipment and Supplies

Keywords

  • Asperger's disorder
  • Autism
  • Brain lateralization
  • Handedness
  • Neuropsychology
  • Pervasive developmental disorders

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

Cite this

Abnormal Brain Lateralization in High-Functioning Autism. / Escalante-Mead, Paul R.; Minshew, Nancy J.; Sweeney, John A.

In: Journal of Autism and Developmental Disorders, Vol. 33, No. 5, 10.2003, p. 539-543.

Research output: Contribution to journalArticle

Escalante-Mead, Paul R. ; Minshew, Nancy J. ; Sweeney, John A. / Abnormal Brain Lateralization in High-Functioning Autism. In: Journal of Autism and Developmental Disorders. 2003 ; Vol. 33, No. 5. pp. 539-543.
@article{c749005b665b480f87e13f1b8d71af03,
title = "Abnormal Brain Lateralization in High-Functioning Autism",
abstract = "Disturbances in lateral preference in autism are of interest because of their potential to shed light on brain maturational processes in this disorder. Forty-seven autistic individuals with a history of disordered early language development and 22 autistic individuals with normal early language acquisition were matched with 112 healthy individuals and compared on a standardized measure of lateral preference, the Edinburgh Handedness Inventory. Autistic individuals with a history of early language disturbance showed more atypical cerebral dominance than both healthy participants and autistic individuals with normal early language skills. The data indicated maturational disturbances in establishing lateral preference rather than increased rates of left handedness. Atypical establishment of cerebral dominance may be one cause of disordered language development in autism.",
keywords = "Asperger's disorder, Autism, Brain lateralization, Handedness, Neuropsychology, Pervasive developmental disorders",
author = "Escalante-Mead, {Paul R.} and Minshew, {Nancy J.} and Sweeney, {John A.}",
year = "2003",
month = "10",
doi = "10.1023/A:1025887713788",
language = "English (US)",
volume = "33",
pages = "539--543",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - Abnormal Brain Lateralization in High-Functioning Autism

AU - Escalante-Mead, Paul R.

AU - Minshew, Nancy J.

AU - Sweeney, John A.

PY - 2003/10

Y1 - 2003/10

N2 - Disturbances in lateral preference in autism are of interest because of their potential to shed light on brain maturational processes in this disorder. Forty-seven autistic individuals with a history of disordered early language development and 22 autistic individuals with normal early language acquisition were matched with 112 healthy individuals and compared on a standardized measure of lateral preference, the Edinburgh Handedness Inventory. Autistic individuals with a history of early language disturbance showed more atypical cerebral dominance than both healthy participants and autistic individuals with normal early language skills. The data indicated maturational disturbances in establishing lateral preference rather than increased rates of left handedness. Atypical establishment of cerebral dominance may be one cause of disordered language development in autism.

AB - Disturbances in lateral preference in autism are of interest because of their potential to shed light on brain maturational processes in this disorder. Forty-seven autistic individuals with a history of disordered early language development and 22 autistic individuals with normal early language acquisition were matched with 112 healthy individuals and compared on a standardized measure of lateral preference, the Edinburgh Handedness Inventory. Autistic individuals with a history of early language disturbance showed more atypical cerebral dominance than both healthy participants and autistic individuals with normal early language skills. The data indicated maturational disturbances in establishing lateral preference rather than increased rates of left handedness. Atypical establishment of cerebral dominance may be one cause of disordered language development in autism.

KW - Asperger's disorder

KW - Autism

KW - Brain lateralization

KW - Handedness

KW - Neuropsychology

KW - Pervasive developmental disorders

UR - http://www.scopus.com/inward/record.url?scp=0242268427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242268427&partnerID=8YFLogxK

U2 - 10.1023/A:1025887713788

DO - 10.1023/A:1025887713788

M3 - Article

C2 - 14594334

AN - SCOPUS:0242268427

VL - 33

SP - 539

EP - 543

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 5

ER -