Abnormal metabolism of free fatty acids in hypertriglyceridaemic men: Apparent insulin resistance of adipose tissue

J. M. Mostaza, Gloria L Vega, P. Snell, Scott M Grundy

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective. There is growing evidence that endogenous hypertriglyceridaemia is frequently accompanied by a state of insulin resistance. The present study was performed to determine whether patients with primary endogenous hypertriglyceridaemia commonly have abnormalities in plasma concentrations and turnover rates of free fatty acids (FFA), which could reflect a state of insulin resistance in adipose tissue and could account for raised plasma triglycerides. Design. Hypertriglyceridaemic and normotriglyceridemic control patients underwent measurements of plasma concentrations and turnover rates of FFA. Fat weights in both groups were determined by hydrodensitometry, and fat distribution was assessed by skin- folds and measurement of waist and hip circumferences. Other measurements included plasma glucose, insulin, lipids, and lipoproteins. Subjects. Fifteen men with normal plasma triglycerides and 21 men with primary endogenous hypertriglyceridaemia were studied. Men in both groups varied in body weights and total fat weights, but total fat weights were entirely overlapping for the two groups. Waist-to-hip ratios and waist circumferences also were similar for the two groups. Results. For any total body fat content or waist circumference, most hypertriglyceridaemia patients had higher mean plasma concentrations of FFA and higher turnover rates (flux) for FFA than did normotriglyceridemic patients. Hypertriglyceridaemic patients also had higher fasting insulin concentrations for a given body fat content. In general, both FFA flux and plasma insulin levels were positively correlated with plasma concentrations of triglyceride and inversely with high density lipoprotein (HDL) cholesterol. Conclusions. These studies indicate that many patients with primary endogenous hypertriglyceridaemia have increased flux of FFA and hyperinsulinemia that cannot be explained either by increased total body fat content or by greater waist circumferences than observed in normotriglyceridemic patients.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalJournal of Internal Medicine
Volume243
Issue number4
DOIs
StatePublished - 1998

Fingerprint

Nonesterified Fatty Acids
Insulin Resistance
Adipose Tissue
Hypertriglyceridemia
Waist Circumference
Fats
Triglycerides
Insulin
Weights and Measures
Waist-Hip Ratio
Hyperinsulinism
HDL Cholesterol
Lipoproteins
Hip
Fasting
Body Weight
Lipids
Glucose
Skin

Keywords

  • Fat weight
  • Fatty acids
  • HDL-cholesterol
  • Insulin resistance
  • Triglycerides
  • VLDL-apo B

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Abnormal metabolism of free fatty acids in hypertriglyceridaemic men : Apparent insulin resistance of adipose tissue. / Mostaza, J. M.; Vega, Gloria L; Snell, P.; Grundy, Scott M.

In: Journal of Internal Medicine, Vol. 243, No. 4, 1998, p. 265-274.

Research output: Contribution to journalArticle

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