TY - JOUR
T1 - Abnormal otoconia and calcification in the labyrinths of deaf dalmatian dogs
AU - Rouse, Roland C.
AU - Johnsson, Lars Göran
AU - Wright, Charles G.
AU - Hawkins, Joseph E.
N1 - Funding Information:
This investigation was supported by USPHS Grants NS-05065, NS-I 1672, NS-16236, NS-12706, and Program Project Grant NS-05785; by a grant from the Research Fund of the American Otological Society and by grants from the Paulo SWti6 and the Finska Lakaresdlskapet, Helsinki. The authors are indebted to Mr John C. Lowrey, President, The Dalmatian Research Foundation, York, Pa., for his support of the study, and to several breeders who generously supplied us with deaf dogs from their kennels.
PY - 1984
Y1 - 1984
N2 - Abnormal mineral deposits from the membranous labyrinths of deaf Dalmatian puppies were examined microscopically. Most such deposits were located on the saccular otoconial membrane and were associated with collapse of the saccule and of Reissner's membrane. In both ears of one pup, crystals resembling otoconia were found on the surface of the stria vascularis. In two others, grossly abnormal crystals were seen on the utricular otoconial membrane, and in one of these crystals were also attached to the cupula of the left horizontal canal. In four animals the tectorial membrane was calcified. Most deposits consisted of apatite spherulites, but large multiple crystals (probably of calcite) were occasionally present. Some of the abnormal mineral deposits in the Dalmatian closely resemble those found in man, and they may originate in the same way.
AB - Abnormal mineral deposits from the membranous labyrinths of deaf Dalmatian puppies were examined microscopically. Most such deposits were located on the saccular otoconial membrane and were associated with collapse of the saccule and of Reissner's membrane. In both ears of one pup, crystals resembling otoconia were found on the surface of the stria vascularis. In two others, grossly abnormal crystals were seen on the utricular otoconial membrane, and in one of these crystals were also attached to the cupula of the left horizontal canal. In four animals the tectorial membrane was calcified. Most deposits consisted of apatite spherulites, but large multiple crystals (probably of calcite) were occasionally present. Some of the abnormal mineral deposits in the Dalmatian closely resemble those found in man, and they may originate in the same way.
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U2 - 10.3109/00016488409107535
DO - 10.3109/00016488409107535
M3 - Article
C2 - 6464727
AN - SCOPUS:0021234133
SN - 0001-6489
VL - 98
SP - 61
EP - 71
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 1-2
ER -