TY - JOUR
T1 - Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia
AU - Diwadkar, Vaibhav A.
AU - DeBellis, Michael D.
AU - Sweeney, John A.
AU - Pettegrew, Jay W.
AU - Keshavan, Matcheri S.
N1 - Funding Information:
This work was supported in part by NIMH grants MH45156-01A1 and MH46614 (JWP), and 5 K08 MHO1324-04 (MDDB), a Scottish Rite Schizophrenia Foundation Grant (MSK), the Center for Neurosciences in Mental Disorders (MH 45156), and by funds received from the NIH/NCRR/GCRC (M01 RR00056). We thank Drs. Cameron Carter, Gretchen Haas, Debra M. Montrose, Elizabeth D. Radomsky, and Nina R. Schooler for their help in clinical assessments, and Elizabeth Dick, Rupal Kotwal, and Wright Bagwell for help in analysis.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.
AB - The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.
KW - Corpus callosum
KW - Magnetic resonance imaging
KW - Schizophrenia
KW - Signal intensity
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U2 - 10.1016/S0920-9964(03)00098-7
DO - 10.1016/S0920-9964(03)00098-7
M3 - Article
C2 - 14984888
AN - SCOPUS:1342321796
VL - 67
SP - 277
EP - 282
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -