Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia

Vaibhav A. Diwadkar, Michael D. DeBellis, John A. Sweeney, Jay W. Pettegrew, Matcheri S. Keshavan

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalSchizophrenia Research
Volume67
Issue number2-3
DOIs
StatePublished - Apr 1 2004

Keywords

  • Corpus callosum
  • Magnetic resonance imaging
  • Schizophrenia
  • Signal intensity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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