Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia

Vaibhav A. Diwadkar; Michael D. DeBellis; John A. Sweeney; Jay W. Pettegrew; Matcheri S. Keshavan

doi:10.1016/S0920-9964(03)00098-7

Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia

Vaibhav A. Diwadkar, Michael D. DeBellis, John A. Sweeney, Jay W. Pettegrew, Matcheri S. Keshavan

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T₁-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.

Original language	English (US)
Pages (from-to)	277-282
Number of pages	6
Journal	Schizophrenia Research
Volume	67
Issue number	2-3
DOIs	https://doi.org/10.1016/S0920-9964(03)00098-7
State	Published - Apr 1 2004

Keywords

Corpus callosum
Magnetic resonance imaging
Schizophrenia
Signal intensity

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/S0920-9964(03)00098-7

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abstract = "The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.",

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