TY - JOUR
T1 - Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia
AU - Diwadkar, Vaibhav A.
AU - DeBellis, Michael D.
AU - Sweeney, John A.
AU - Pettegrew, Jay W.
AU - Keshavan, Matcheri S.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.
AB - The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.
KW - Corpus callosum
KW - Magnetic resonance imaging
KW - Schizophrenia
KW - Signal intensity
UR - http://www.scopus.com/inward/record.url?scp=1342321796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1342321796&partnerID=8YFLogxK
U2 - 10.1016/S0920-9964(03)00098-7
DO - 10.1016/S0920-9964(03)00098-7
M3 - Article
C2 - 14984888
AN - SCOPUS:1342321796
VL - 67
SP - 277
EP - 282
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -