@article{0bc2c621273a40419d7e013691f37866,
title = "Abnormalities of hippocampal shape and subfield volumes in medication-free patients with obsessive–compulsive disorder",
abstract = "In this study, we sought to identify alterations of hippocampal shape and subfield volumes in a relatively large sample of medication-free obsessive–compulsive disorder (OCD) patients without comorbid depression. 3D T1-weighted Magnetic Resonance Imaging scans were collected from 81 medication-free OCD patients and 95 age- and sex-matched healthy controls (HC). Total hippocampal volume and volume of eight bilateral subfields were measured using FreeSurfer software. Subregional shape deformity was examined via FSL software. Volumetric and shape differences between groups and correlations with OCD symptoms were examined. The volume of right hippocampus was significantly reduced in OCD patients (p =.001, η2 = 0.065). Follow-up analysis of right hemisphere subfields showed reduced volume in right subiculum (p <.001, η2 = 0.081), presubiculum (p <.001, η2 = 0.125), CA2/3 (p =.001, η2 = 0.06), and hippocampal tail (p < 0.001, η2 = 0.105), while the volume of right fimbria was increased (p =.001, η2 = 0.058). Shape analysis revealed a bilateral outward bending in the hippocampal body related to a lateral displacement of hippocampus from the body to the tail. Symptom severity was correlated with volumes of presubiculum (with compulsions, r = −0.25, p =.024) and fimbria (with obsessions, r = −0.28, p =.012), and with the lateral shift of middle and posterior hippocampus (with obsessions). Alterations across hippocampal subfields and overall shape may contribute to the distinctive cognitive and affective abnormalities associated with OCD.",
keywords = "MRI, fimbria, hippocampus, obsessive–compulsive disorder, psychoradiology, subiculum",
author = "Lianqing Zhang and Xinyu Hu and Lu Lu and Bin Li and Xiaoxiao Hu and Xuan Bu and Hailong Li and Shi Tang and Yanchun Yang and Neil Roberts and Sweeney, {John A.} and Qiyong Gong and Xiaoqi Huang",
note = "Funding Information: The authors declare that they have no conflicts of interest. This study was supported by the National Natural Science Foundation (Grant No. 81671669, 81621003, 81171488, 81761128023, 81820108018, 81227002, and 81030027) and Youth Technology Grant of Sichuan Province (No 2017JQ0001), and by an award from the Humboldt Foundation to Dr. Sweeney, and Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT, Grant No. IRT16R52) of China, and NIH/NIMH R01MH112189?01 of USA. Dr. Gong would also like to acknowledge the support from his Changjiang Scholar Professorship Award (Award No. T2014190) of China and American CMB Distinguished Professorship Award (Award No. F510000/G16916411) administered by the Institute of International Education, USA. Funding Information: The authors declare that they have no conflicts of interest. This study was supported by the National Natural Science Foundation (Grant No. 81671669, 81621003, 81171488, 81761128023, 81820108018, 81227002, and 81030027) and Youth Technology Grant of Sichuan Province (No 2017JQ0001), and by an award from the Humboldt Foundation to Dr. Sweeney, and Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT, Grant No. IRT16R52) of China, and NIH/NIMH R01MH112189–01 of USA. Dr. Gong would also like to acknowledge the support from his Changjiang Scholar Professorship Award (Award No. T2014190) of China and American CMB Distinguished Professorship Award (Award No. F510000/G16916411) administered by the Institute of International Education, USA. Funding Information: Changjiang Scholar Professorship Award, Grant/Award Number: T2014190; National Natural Science Foundation of China, Grant/ Award Numbers: 81171488, 81030027, 81227002, 81621003, 81671669, 81761128023, 81820108018; Program for Changjiang Scholars and Innovative Research Team in University, Grant/Award Number: IRT16R52; the Humboldt Foundation; Youth Technology Grant of Sichuan Province, Grant/ Award Number: 2017JQ0001 Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = oct,
doi = "10.1002/hbm.24688",
language = "English (US)",
volume = "40",
pages = "4105--4113",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "14",
}