Abnormalities of hippocampal shape and subfield volumes in medication-free patients with obsessive–compulsive disorder

Lianqing Zhang, Xinyu Hu, Lu Lu, Bin Li, Xiaoxiao Hu, Xuan Bu, Hailong Li, Shi Tang, Yanchun Yang, Neil Roberts, John A. Sweeney, Qiyong Gong, Xiaoqi Huang

Research output: Contribution to journalArticle

Abstract

In this study, we sought to identify alterations of hippocampal shape and subfield volumes in a relatively large sample of medication-free obsessive–compulsive disorder (OCD) patients without comorbid depression. 3D T1-weighted Magnetic Resonance Imaging scans were collected from 81 medication-free OCD patients and 95 age- and sex-matched healthy controls (HC). Total hippocampal volume and volume of eight bilateral subfields were measured using FreeSurfer software. Subregional shape deformity was examined via FSL software. Volumetric and shape differences between groups and correlations with OCD symptoms were examined. The volume of right hippocampus was significantly reduced in OCD patients (p =.001, η2 = 0.065). Follow-up analysis of right hemisphere subfields showed reduced volume in right subiculum (p <.001, η2 = 0.081), presubiculum (p <.001, η2 = 0.125), CA2/3 (p =.001, η2 = 0.06), and hippocampal tail (p < 0.001, η2 = 0.105), while the volume of right fimbria was increased (p =.001, η2 = 0.058). Shape analysis revealed a bilateral outward bending in the hippocampal body related to a lateral displacement of hippocampus from the body to the tail. Symptom severity was correlated with volumes of presubiculum (with compulsions, r = −0.25, p =.024) and fimbria (with obsessions, r = −0.28, p =.012), and with the lateral shift of middle and posterior hippocampus (with obsessions). Alterations across hippocampal subfields and overall shape may contribute to the distinctive cognitive and affective abnormalities associated with OCD.

Original languageEnglish (US)
Pages (from-to)4105-4113
Number of pages9
JournalHuman Brain Mapping
Volume40
Issue number14
DOIs
StatePublished - 2019

Keywords

  • MRI
  • fimbria
  • hippocampus
  • obsessive–compulsive disorder
  • psychoradiology
  • subiculum

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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  • Cite this

    Zhang, L., Hu, X., Lu, L., Li, B., Hu, X., Bu, X., Li, H., Tang, S., Yang, Y., Roberts, N., Sweeney, J. A., Gong, Q., & Huang, X. (2019). Abnormalities of hippocampal shape and subfield volumes in medication-free patients with obsessive–compulsive disorder. Human Brain Mapping, 40(14), 4105-4113. https://doi.org/10.1002/hbm.24688