Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.

D. A. Clayton; J. N. Doda; E. C. Friedberg

doi:10.1007/978-1-4684-2898-8_26

Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.

D. A. Clayton, J. N. Doda, E. C. Friedberg

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Abstract

We have assayed the ability of mammalian cells to remove pyrimidine dimers from their mitochondrial DNA. The results indicate that pyrimidine dimers are not repaired for as long as 48 hr after UV irradiation. Furthermore, molecules containing pyrimidine dimers are unable to replicate and are simply diluted out in subsequent cell divisions.

Original language	English (US)
Pages (from-to)	589-591
Number of pages	3
Journal	Basic life sciences
Volume	5 B
DOIs	https://doi.org/10.1007/978-1-4684-2898-8_26
State	Published - 1975

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4684-2898-8_26

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title = "Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.",

abstract = "We have assayed the ability of mammalian cells to remove pyrimidine dimers from their mitochondrial DNA. The results indicate that pyrimidine dimers are not repaired for as long as 48 hr after UV irradiation. Furthermore, molecules containing pyrimidine dimers are unable to replicate and are simply diluted out in subsequent cell divisions.",

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AU - Clayton, D. A.

AU - Doda, J. N.

AU - Friedberg, E. C.

PY - 1975

Y1 - 1975

N2 - We have assayed the ability of mammalian cells to remove pyrimidine dimers from their mitochondrial DNA. The results indicate that pyrimidine dimers are not repaired for as long as 48 hr after UV irradiation. Furthermore, molecules containing pyrimidine dimers are unable to replicate and are simply diluted out in subsequent cell divisions.

AB - We have assayed the ability of mammalian cells to remove pyrimidine dimers from their mitochondrial DNA. The results indicate that pyrimidine dimers are not repaired for as long as 48 hr after UV irradiation. Furthermore, molecules containing pyrimidine dimers are unable to replicate and are simply diluted out in subsequent cell divisions.

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DO - 10.1007/978-1-4684-2898-8_26

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AN - SCOPUS:0016625683

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JO - Basic life sciences

JF - Basic life sciences

ER -

Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells.

Abstract

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