Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE

Y. Q. Song, E. Rogaeva, S. Premkumar, N. Brindle, T. Kawarai, An Orlacchio, G. Yu, G. Levesque, M. Nishimura, M. Ikeda, Y. Pei, C. O'Toole, R. Duara, W. Barker, S. Sorbi, M. Freedman, L. Farrer, P. St. George-Hyslop

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Abstract

A novel polymorphism (-491 A/T) within the regulatory region on the apolipoprotein E gene has recently been reported to be associated with risk for Alzheimer disease (AD). To test this association in an independent data set, we have examined this polymorphism in a sample of 88 well-characterized AD cases and compared the allele frequency and genotype frequencies for this polymorphism with those observed in 112 cegnitively normal subjects drawn from the same ethnic group. These results suggest that in the current data set at least, the -491 NT polymorphism is not associated with risk for AD, but may be in partial linkage disequilibrium with the APOE ε2/ε3/ε4 polymorphism.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalNeuroscience Letters
Volume250
Issue number3
DOIs
StatePublished - Jul 10 1998

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Nucleic Acid Regulatory Sequences
Alzheimer Disease
Linkage Disequilibrium
Apolipoproteins E
Ethnic Groups
Gene Frequency
Genotype
Genes
Datasets

Keywords

  • -491 A/T polymorphism
  • Alzheimer disease
  • APOE ε2/ε3/ε4 polymorphism

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Song, Y. Q., Rogaeva, E., Premkumar, S., Brindle, N., Kawarai, T., Orlacchio, A., ... St. George-Hyslop, P. (1998). Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE. Neuroscience Letters, 250(3), 189-192. https://doi.org/10.1016/S0304-3940(98)00470-4

Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE. / Song, Y. Q.; Rogaeva, E.; Premkumar, S.; Brindle, N.; Kawarai, T.; Orlacchio, An; Yu, G.; Levesque, G.; Nishimura, M.; Ikeda, M.; Pei, Y.; O'Toole, C.; Duara, R.; Barker, W.; Sorbi, S.; Freedman, M.; Farrer, L.; St. George-Hyslop, P.

In: Neuroscience Letters, Vol. 250, No. 3, 10.07.1998, p. 189-192.

Research output: Contribution to journalArticle

Song, YQ, Rogaeva, E, Premkumar, S, Brindle, N, Kawarai, T, Orlacchio, A, Yu, G, Levesque, G, Nishimura, M, Ikeda, M, Pei, Y, O'Toole, C, Duara, R, Barker, W, Sorbi, S, Freedman, M, Farrer, L & St. George-Hyslop, P 1998, 'Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE', Neuroscience Letters, vol. 250, no. 3, pp. 189-192. https://doi.org/10.1016/S0304-3940(98)00470-4
Song, Y. Q. ; Rogaeva, E. ; Premkumar, S. ; Brindle, N. ; Kawarai, T. ; Orlacchio, An ; Yu, G. ; Levesque, G. ; Nishimura, M. ; Ikeda, M. ; Pei, Y. ; O'Toole, C. ; Duara, R. ; Barker, W. ; Sorbi, S. ; Freedman, M. ; Farrer, L. ; St. George-Hyslop, P. / Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE. In: Neuroscience Letters. 1998 ; Vol. 250, No. 3. pp. 189-192.
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