Absence of metabolic cooperation in PHA-stimulated human lymphocyte cultures

R. P. Cox, M. R. Krauss, M. E. Balis, J. Dancis

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Intercellular communication as detected by ionic coupling and gap junction formation has been reported previously in phytohemagglutinin (PHA)-stimulated lymphocyte cultures. PHA-stimulated mixtures of normal and hypoxanthine phosphoribosyl-transferase (HPRT) deficient lymphocytes did not exhibit metabolic cooperation when incubated with [3H]hypoxanthine. These observations suggest that there may be selectivity for compounds transferred by lymphocyte junctions during intercellular communication.

Original languageEnglish (US)
Pages (from-to)411-414
Number of pages4
JournalExperimental Cell Research
Volume101
Issue number2
DOIs
StatePublished - Sep 1976

ASJC Scopus subject areas

  • Cell Biology

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