Intercellular communication as detected by ionic coupling and gap junction formation has been reported previously in phytohemagglutinin (PHA)-stimulated lymphocyte cultures. PHA-stimulated mixtures of normal and hypoxanthine phosphoribosyl-transferase (HPRT) deficient lymphocytes did not exhibit metabolic cooperation when incubated with [3H]hypoxanthine. These observations suggest that there may be selectivity for compounds transferred by lymphocyte junctions during intercellular communication.
ASJC Scopus subject areas
- Cell Biology