Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin

M. I. Rendon; Ponciano D Cruz; R. D. Sontheimer; P. R. Bergstresser

doi:10.1016/S0190-9622(89)70208-5

Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin

M. I. Rendon, Ponciano D Cruz, R. D. Sontheimer, P. R. Bergstresser

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102 Scopus citations

Abstract

Tissue resistance to insulin is a major feature underlying the development of acanthosis nigricans in many patients. We report two unusual cases of acanthosis nigricans with contrasting forms of insulin resistance and propose an algorithm for the evaluation of patients with acanthosis nigricans. Further, we present a schematic framework that emphasizes the role of insulin and insulin growth factors in the pathogenesis of acanthosis nigricans.

Original language	English (US)
Pages (from-to)	461-469
Number of pages	9
Journal	Journal of the American Academy of Dermatology
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/S0190-9622(89)70208-5
State	Published - 1989

ASJC Scopus subject areas

Dermatology

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10.1016/S0190-9622(89)70208-5

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title = "Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin",

abstract = "Tissue resistance to insulin is a major feature underlying the development of acanthosis nigricans in many patients. We report two unusual cases of acanthosis nigricans with contrasting forms of insulin resistance and propose an algorithm for the evaluation of patients with acanthosis nigricans. Further, we present a schematic framework that emphasizes the role of insulin and insulin growth factors in the pathogenesis of acanthosis nigricans.",

author = "Rendon, {M. I.} and Cruz, {Ponciano D} and Sontheimer, {R. D.} and Bergstresser, {P. R.}",

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T1 - Acanthosis nigricans

T2 - A cutaneous marker of tissue resistance to insulin

AU - Rendon, M. I.

AU - Cruz, Ponciano D

AU - Sontheimer, R. D.

AU - Bergstresser, P. R.

PY - 1989

Y1 - 1989

N2 - Tissue resistance to insulin is a major feature underlying the development of acanthosis nigricans in many patients. We report two unusual cases of acanthosis nigricans with contrasting forms of insulin resistance and propose an algorithm for the evaluation of patients with acanthosis nigricans. Further, we present a schematic framework that emphasizes the role of insulin and insulin growth factors in the pathogenesis of acanthosis nigricans.

AB - Tissue resistance to insulin is a major feature underlying the development of acanthosis nigricans in many patients. We report two unusual cases of acanthosis nigricans with contrasting forms of insulin resistance and propose an algorithm for the evaluation of patients with acanthosis nigricans. Further, we present a schematic framework that emphasizes the role of insulin and insulin growth factors in the pathogenesis of acanthosis nigricans.

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U2 - 10.1016/S0190-9622(89)70208-5

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JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 3

ER -

Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin

Abstract

ASJC Scopus subject areas

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