Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin

M. I. Rendon, Ponciano D Cruz, R. D. Sontheimer, P. R. Bergstresser

Research output: Contribution to journalArticle

90 Scopus citations


Tissue resistance to insulin is a major feature underlying the development of acanthosis nigricans in many patients. We report two unusual cases of acanthosis nigricans with contrasting forms of insulin resistance and propose an algorithm for the evaluation of patients with acanthosis nigricans. Further, we present a schematic framework that emphasizes the role of insulin and insulin growth factors in the pathogenesis of acanthosis nigricans.

Original languageEnglish (US)
Pages (from-to)461-469
Number of pages9
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Jan 1 1989


ASJC Scopus subject areas

  • Dermatology

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