Accelerated partial breast irradiation

Nina N. Sanford, Alphonse G. Taghian

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Traditionally, the treatment for early-stage breast cancer has included lumpectomy followed by whole breast radiotherapy over 5-6 weeks. Due to the inconvenience and cost of this schedule along with concern that targeting the whole breast may be overtreatment from some patients, accelerated partial breast irradiation (APBI) has been explored as an alternative radiotherapy strategy. APBI shortens breast radiotherapy to 1 week or less by increasing the dose per fraction while decreasing the treatment volume to the tumor bed alone. Generally, APBI is restricted to patients with the lowest risk disease; however, the results of ongoing trials may potentially broaden eligibility. APBI can be accomplished via multiple techniques including (1) multicatheter interstitial brachytherapy, (2) balloon-based brachytherapy (MammoSite), (3) external beam radiotherapy, and (4) intraoperative radiotherapy. These methods differ in their degree of invasiveness, treatment time, radiation dose, and exact volume of breast tissue irradiated. Based on Phase I, II, and more recently Phase III studies, each of these techniques can achieve excellent local control rates with low toxicity when performed correctly. The anticipated publication of several large Phase III studies in the coming years will help to further define patient selection criteria and determine the appropriate APBI technique for each clinical setting.

Original languageEnglish (US)
Title of host publicationBreast Cancer
Subtitle of host publicationInnovations in Research and Management
PublisherSpringer International Publishing
Pages655-669
Number of pages15
ISBN (Electronic)9783319488486
ISBN (Print)9783319488462
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Radiotherapy
Breast
Irradiation
Brachytherapy
Balloons
Patient Selection
Dosimetry
Toxicity
Tumors
Tissue
Segmental Mastectomy
Tumor Burden
Publications
Appointments and Schedules
Therapeutics
Costs
Radiation
Breast Neoplasms
Costs and Cost Analysis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sanford, N. N., & Taghian, A. G. (2017). Accelerated partial breast irradiation. In Breast Cancer: Innovations in Research and Management (pp. 655-669). Springer International Publishing. https://doi.org/10.1007/978-3-319-48848-6_55

Accelerated partial breast irradiation. / Sanford, Nina N.; Taghian, Alphonse G.

Breast Cancer: Innovations in Research and Management. Springer International Publishing, 2017. p. 655-669.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sanford, NN & Taghian, AG 2017, Accelerated partial breast irradiation. in Breast Cancer: Innovations in Research and Management. Springer International Publishing, pp. 655-669. https://doi.org/10.1007/978-3-319-48848-6_55
Sanford NN, Taghian AG. Accelerated partial breast irradiation. In Breast Cancer: Innovations in Research and Management. Springer International Publishing. 2017. p. 655-669 https://doi.org/10.1007/978-3-319-48848-6_55
Sanford, Nina N. ; Taghian, Alphonse G. / Accelerated partial breast irradiation. Breast Cancer: Innovations in Research and Management. Springer International Publishing, 2017. pp. 655-669
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