Acceptability by rats of aqueous solutions of amino acid analogues

Jean K. Tews, Joyce J. Repa, Alfred E. Harper

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Preferences differed widely when rats were offered choices between water and solutions of various natural amino acids and structurally related analogues. They avoided the branched-chain amino acid valine but preferred solutions of its isomer norvaline and of norleucine. The hydrochloride forms of ornithine and arginine were preferred to water at concentrations up to about 100 mM and avoided at 410 mM; homoarginine·HCl was never preferred and was avoided at 39 and 78 mM. Rats were indifferent to taurine and β-alanine at most concentrations but refused these amino acids at high concentrations (205 and 410 mM, respectively). In conjunction with earlier observations on feeding behavior in response to dietary additions of amino acids, the results show that selections by rats between water and amino acid solutions cannot be used to predict choices among amino acid-containing diets.

Original languageEnglish (US)
Pages (from-to)525-528
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume28
Issue number4
DOIs
StatePublished - 1987

Fingerprint

Rats
Amino Acids
Water
Norleucine
Branched Chain Amino Acids
Ornithine
Taurine
Valine
Feeding Behavior
Nutrition
Isomers
Alanine
Arginine
Diet

Keywords

  • Amino acid analogues
  • Branched-chain amino acids
  • Cationic amino acids
  • Choice
  • Drinking
  • Rats
  • Taste

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Acceptability by rats of aqueous solutions of amino acid analogues. / Tews, Jean K.; Repa, Joyce J.; Harper, Alfred E.

In: Pharmacology, Biochemistry and Behavior, Vol. 28, No. 4, 1987, p. 525-528.

Research output: Contribution to journalArticle

@article{142b2ab871254dcab8ce26d0f0decff8,
title = "Acceptability by rats of aqueous solutions of amino acid analogues",
abstract = "Preferences differed widely when rats were offered choices between water and solutions of various natural amino acids and structurally related analogues. They avoided the branched-chain amino acid valine but preferred solutions of its isomer norvaline and of norleucine. The hydrochloride forms of ornithine and arginine were preferred to water at concentrations up to about 100 mM and avoided at 410 mM; homoarginine·HCl was never preferred and was avoided at 39 and 78 mM. Rats were indifferent to taurine and β-alanine at most concentrations but refused these amino acids at high concentrations (205 and 410 mM, respectively). In conjunction with earlier observations on feeding behavior in response to dietary additions of amino acids, the results show that selections by rats between water and amino acid solutions cannot be used to predict choices among amino acid-containing diets.",
keywords = "Amino acid analogues, Branched-chain amino acids, Cationic amino acids, Choice, Drinking, Rats, Taste",
author = "Tews, {Jean K.} and Repa, {Joyce J.} and Harper, {Alfred E.}",
year = "1987",
doi = "10.1016/0091-3057(87)90517-X",
language = "English (US)",
volume = "28",
pages = "525--528",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Acceptability by rats of aqueous solutions of amino acid analogues

AU - Tews, Jean K.

AU - Repa, Joyce J.

AU - Harper, Alfred E.

PY - 1987

Y1 - 1987

N2 - Preferences differed widely when rats were offered choices between water and solutions of various natural amino acids and structurally related analogues. They avoided the branched-chain amino acid valine but preferred solutions of its isomer norvaline and of norleucine. The hydrochloride forms of ornithine and arginine were preferred to water at concentrations up to about 100 mM and avoided at 410 mM; homoarginine·HCl was never preferred and was avoided at 39 and 78 mM. Rats were indifferent to taurine and β-alanine at most concentrations but refused these amino acids at high concentrations (205 and 410 mM, respectively). In conjunction with earlier observations on feeding behavior in response to dietary additions of amino acids, the results show that selections by rats between water and amino acid solutions cannot be used to predict choices among amino acid-containing diets.

AB - Preferences differed widely when rats were offered choices between water and solutions of various natural amino acids and structurally related analogues. They avoided the branched-chain amino acid valine but preferred solutions of its isomer norvaline and of norleucine. The hydrochloride forms of ornithine and arginine were preferred to water at concentrations up to about 100 mM and avoided at 410 mM; homoarginine·HCl was never preferred and was avoided at 39 and 78 mM. Rats were indifferent to taurine and β-alanine at most concentrations but refused these amino acids at high concentrations (205 and 410 mM, respectively). In conjunction with earlier observations on feeding behavior in response to dietary additions of amino acids, the results show that selections by rats between water and amino acid solutions cannot be used to predict choices among amino acid-containing diets.

KW - Amino acid analogues

KW - Branched-chain amino acids

KW - Cationic amino acids

KW - Choice

KW - Drinking

KW - Rats

KW - Taste

UR - http://www.scopus.com/inward/record.url?scp=0023507241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023507241&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(87)90517-X

DO - 10.1016/0091-3057(87)90517-X

M3 - Article

C2 - 3432318

AN - SCOPUS:0023507241

VL - 28

SP - 525

EP - 528

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -