Accuracy of volumetric flow rate measurements

An in vitro study using modern ultrasound scanners

Kenneth Hoyt, Felix A. Hester, Randall L. Bell, Mark E. Lockhart, Michelle L. Robbin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective. Volumetric flow measurement with Doppler ultrasound is useful in assessing blood flow as part of an evaluation of arteriovenous fistula maturity in patients undergoing hemodialysis. In this study, we assessed both accuracy and variability in volumetric flow measurements obtained using modern and commercially available ultrasound systems and an in vitro experimental setup. Methods. Volumetric flow measurements using duplex ultrasound were obtained by 3 users operating 5 different systems for randomized flow in the range of 100 to 1000 mL/min. Users performed 3 consecutive measurements at a given flow rate. Data were analyzed using statistical techniques to assess measurement accuracy and variability. Results. Over the span of flow rates studied, the root mean square error (RMSE) for the 5 ultrasound systems ranged from 38.8 to 79.7, 36.8 to 52.0, 73.0 to 85.3, 26.7 to 44.6, and 43.9 to 93.5 mL/min. Corresponding average RMSE values were 60.3, 42.7, 81.1, 37.2, and 64.4 mL/min, respectively. A linear regression analysis of mean interobserver measurements revealed an excellent correlation for all ultrasound systems (r2 > 99.1%). Assessment of intraobserver measurements revealed no statistically significant differences for any ultrasound system evaluated (P > .94). Comparison of interobserver measurements indicates no statistically significant differences between any of the 5 systems (P > .14). Conclusions. Modern ultrasound systems are reasonably accurate in blood flow measurement in an experimental setup mimicking clinically relevant blood flow ranges in a hemodialysis fistula. Users need adequate training and experience to perform multiple measurements and use appropriate techniques to minimize errors in flow measurement.

Original languageEnglish (US)
Pages (from-to)1511-1518
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2009

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Renal Dialysis
Doppler Ultrasonography
Arteriovenous Fistula
Fistula
Linear Models
Regression Analysis
In Vitro Techniques

Keywords

  • Doppler ultrasound
  • Hemodialysis fistula
  • Volumetric flow

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Accuracy of volumetric flow rate measurements : An in vitro study using modern ultrasound scanners. / Hoyt, Kenneth; Hester, Felix A.; Bell, Randall L.; Lockhart, Mark E.; Robbin, Michelle L.

In: Journal of Ultrasound in Medicine, Vol. 28, No. 11, 01.11.2009, p. 1511-1518.

Research output: Contribution to journalArticle

Hoyt, Kenneth ; Hester, Felix A. ; Bell, Randall L. ; Lockhart, Mark E. ; Robbin, Michelle L. / Accuracy of volumetric flow rate measurements : An in vitro study using modern ultrasound scanners. In: Journal of Ultrasound in Medicine. 2009 ; Vol. 28, No. 11. pp. 1511-1518.
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abstract = "Objective. Volumetric flow measurement with Doppler ultrasound is useful in assessing blood flow as part of an evaluation of arteriovenous fistula maturity in patients undergoing hemodialysis. In this study, we assessed both accuracy and variability in volumetric flow measurements obtained using modern and commercially available ultrasound systems and an in vitro experimental setup. Methods. Volumetric flow measurements using duplex ultrasound were obtained by 3 users operating 5 different systems for randomized flow in the range of 100 to 1000 mL/min. Users performed 3 consecutive measurements at a given flow rate. Data were analyzed using statistical techniques to assess measurement accuracy and variability. Results. Over the span of flow rates studied, the root mean square error (RMSE) for the 5 ultrasound systems ranged from 38.8 to 79.7, 36.8 to 52.0, 73.0 to 85.3, 26.7 to 44.6, and 43.9 to 93.5 mL/min. Corresponding average RMSE values were 60.3, 42.7, 81.1, 37.2, and 64.4 mL/min, respectively. A linear regression analysis of mean interobserver measurements revealed an excellent correlation for all ultrasound systems (r2 > 99.1{\%}). Assessment of intraobserver measurements revealed no statistically significant differences for any ultrasound system evaluated (P > .94). Comparison of interobserver measurements indicates no statistically significant differences between any of the 5 systems (P > .14). Conclusions. Modern ultrasound systems are reasonably accurate in blood flow measurement in an experimental setup mimicking clinically relevant blood flow ranges in a hemodialysis fistula. Users need adequate training and experience to perform multiple measurements and use appropriate techniques to minimize errors in flow measurement.",
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