Accurate segmentation of brain images into 34 structures combining a non-stationary adaptive statistical atlas and a multi-atlas with applications to Alzheimer'S disease

Zhennan Yan, Shaoting Zhang, Xiaofeng Liu, Dimitris N. Metaxas, Albert Montillo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

Accurate segmentation of the 30+ subcortical structures in MR images of whole diseased brains is challenging due to inter-subject variability and complex geometry of brain anatomy. However a clinically viable solution yielding precise segmentation of the structures would enable: 1) accurate, objective measurement of structure volumes many of which are associated with diseases such as Alzheimer's, 2) therapy monitoring and 3) drug development. Our contributions are two-fold. First we construct an extended adaptive statistical atlas method (EASA) to use a non-stationary relaxation factor rather than a global one. This permits finer control over adaptivity allowing 34 structures to be simultaneously segmented rather than just 4 as in [13]. Second we use the output of a weighted majority voting (WMV) label fusion multi-atlas method as the input to EASA in a hybrid WMV-EASA approach. We assess our proposed approaches on 18 healthy subjects in the public IBSR database and on 9 subjects with Alzheimer's disease in the AIBL database. EASA is shown to produce state-of-the-art accuracy on healthy brains in a fraction of the time of comparable methods, while our hybrid WMV-EASA visibly improves segmentation accuracy for structures throughout the diseased brains.

Original languageEnglish (US)
Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro
Pages1202-1205
Number of pages4
DOIs
StatePublished - Aug 22 2013
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: Apr 7 2013Apr 11 2013

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period4/7/134/11/13

Keywords

  • Alzheimer's
  • Dirichlet distribution
  • EM
  • MRF
  • brain segmentation
  • label fusion
  • statistical atlas

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Yan, Z., Zhang, S., Liu, X., Metaxas, D. N., & Montillo, A. (2013). Accurate segmentation of brain images into 34 structures combining a non-stationary adaptive statistical atlas and a multi-atlas with applications to Alzheimer'S disease. In ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro (pp. 1202-1205). [6556696] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2013.6556696