@article{4f3cf8acf49447bcb52484c5d9d22401,
title = "Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes",
abstract = "The decision by a cell to enter a round of growth and division must be intimately coordinated with nutrient availability and its metabolic state. These metabolic and nutritional requirements, and the mechanisms by which they induce cell growth and proliferation, remain poorly understood. Herein, we report that acetyl-CoA is the downstream metabolite of carbon sources that represents a critical metabolic signal for growth and proliferation. Upon entry into growth, intracellular acetyl-CoA levels increase substantially and consequently induce the Gcn5p/SAGA-catalyzed acetylation of histones at genes important for growth, thereby enabling their rapid transcription and commitment to growth. Thus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes.",
author = "Ling Cai and Sutter, {Benjamin M.} and Bing Li and Tu, {Benjamin P.}",
note = "Funding Information: We thank Jerry Workman, Joe Reese, and Cheng-Ming Chiang for generously sharing antibodies; the UTSW Protein Chemistry Technology Core Facility and the Scripps Center for Mass Spectrometry for protein identification and posttranslational modification analysis; the UTSW Microarray Core for Illumina sequencing; Zheng Kuang and Mark Borromeo for help with ChIP-Seq analysis; and Steve McKnight, Sung Chan Kim, Michael Springer, Noah Dephoure, Sean Taverna, Ralph Deberardinis, Kosaku Uyeda, and members of the Tu Lab for helpful discussions. This work was supported by the UTSW Endowed Scholars Program (B.P.T.), a Burroughs Wellcome Fund Career Award in Biomedical Sciences (B.P.T.), a Welch Foundation Research Grant I-1697 (B.P.T.), award R01GM094314 from the National Institute of General Medical Sciences (B.P.T.), a David and Lucile Packard Foundation Fellowship (B.P.T.), a Damon Runyon-Rachleff Innovation Award (B.P.T.), and a Frank and Sara McKnight Graduate Fellowship (L.C.). ",
year = "2011",
month = may,
day = "20",
doi = "10.1016/j.molcel.2011.05.004",
language = "English (US)",
volume = "42",
pages = "426--437",
journal = "Molecular cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "4",
}