Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

Ling Cai, Benjamin M. Sutter, Bing Li, Benjamin P. Tu

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

The decision by a cell to enter a round of growth and division must be intimately coordinated with nutrient availability and its metabolic state. These metabolic and nutritional requirements, and the mechanisms by which they induce cell growth and proliferation, remain poorly understood. Herein, we report that acetyl-CoA is the downstream metabolite of carbon sources that represents a critical metabolic signal for growth and proliferation. Upon entry into growth, intracellular acetyl-CoA levels increase substantially and consequently induce the Gcn5p/SAGA-catalyzed acetylation of histones at genes important for growth, thereby enabling their rapid transcription and commitment to growth. Thus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes.

Original languageEnglish (US)
Pages (from-to)426-437
Number of pages12
JournalMolecular Cell
Volume42
Issue number4
DOIs
StatePublished - May 20 2011

Fingerprint

Acetyl Coenzyme A
Acetylation
Histones
Cell Proliferation
Growth
Genes
Carbon
Nutritional Requirements
Food

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes. / Cai, Ling; Sutter, Benjamin M.; Li, Bing; Tu, Benjamin P.

In: Molecular Cell, Vol. 42, No. 4, 20.05.2011, p. 426-437.

Research output: Contribution to journalArticle

@article{4f3cf8acf49447bcb52484c5d9d22401,
title = "Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes",
abstract = "The decision by a cell to enter a round of growth and division must be intimately coordinated with nutrient availability and its metabolic state. These metabolic and nutritional requirements, and the mechanisms by which they induce cell growth and proliferation, remain poorly understood. Herein, we report that acetyl-CoA is the downstream metabolite of carbon sources that represents a critical metabolic signal for growth and proliferation. Upon entry into growth, intracellular acetyl-CoA levels increase substantially and consequently induce the Gcn5p/SAGA-catalyzed acetylation of histones at genes important for growth, thereby enabling their rapid transcription and commitment to growth. Thus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes.",
author = "Ling Cai and Sutter, {Benjamin M.} and Bing Li and Tu, {Benjamin P.}",
year = "2011",
month = "5",
day = "20",
doi = "10.1016/j.molcel.2011.05.004",
language = "English (US)",
volume = "42",
pages = "426--437",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "4",

}

TY - JOUR

T1 - Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

AU - Cai, Ling

AU - Sutter, Benjamin M.

AU - Li, Bing

AU - Tu, Benjamin P.

PY - 2011/5/20

Y1 - 2011/5/20

N2 - The decision by a cell to enter a round of growth and division must be intimately coordinated with nutrient availability and its metabolic state. These metabolic and nutritional requirements, and the mechanisms by which they induce cell growth and proliferation, remain poorly understood. Herein, we report that acetyl-CoA is the downstream metabolite of carbon sources that represents a critical metabolic signal for growth and proliferation. Upon entry into growth, intracellular acetyl-CoA levels increase substantially and consequently induce the Gcn5p/SAGA-catalyzed acetylation of histones at genes important for growth, thereby enabling their rapid transcription and commitment to growth. Thus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes.

AB - The decision by a cell to enter a round of growth and division must be intimately coordinated with nutrient availability and its metabolic state. These metabolic and nutritional requirements, and the mechanisms by which they induce cell growth and proliferation, remain poorly understood. Herein, we report that acetyl-CoA is the downstream metabolite of carbon sources that represents a critical metabolic signal for growth and proliferation. Upon entry into growth, intracellular acetyl-CoA levels increase substantially and consequently induce the Gcn5p/SAGA-catalyzed acetylation of histones at genes important for growth, thereby enabling their rapid transcription and commitment to growth. Thus, acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes.

UR - http://www.scopus.com/inward/record.url?scp=79955960768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955960768&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2011.05.004

DO - 10.1016/j.molcel.2011.05.004

M3 - Article

VL - 42

SP - 426

EP - 437

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 4

ER -