Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

Glen Liszczak, Katharine L. Diehl, Geoffrey P. Dann, Tom W. Muir

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.

Original languageEnglish (US)
Pages (from-to)837-840
Number of pages4
JournalNature chemical biology
Volume14
Issue number9
DOIs
StatePublished - Sep 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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