Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

C. Geoffrey Davis, Joseph L. Goldstein, Thomas C. Südhof, Richard G W Anderson, David W. Russell, Michael S. Brown

Research output: Contribution to journalArticle

276 Citations (Scopus)

Abstract

A domain in the low-density lipoprotein receptor contains three cysteine-rich 'growth factor' repeats like those that occur in many proteins. When this domain is deleted, the receptor no longer releases its ligand at acid pH, it is no longer recycled efficiently and it is rapidly degraded after ligand binding.

Original languageEnglish (US)
Pages (from-to)760-765
Number of pages6
JournalNature
Volume326
Issue number6115
StatePublished - 1987

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LDL Receptors
Recycling
Intercellular Signaling Peptides and Proteins
Ligands
Acids
Cysteine
Proteins

ASJC Scopus subject areas

  • General

Cite this

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. / Davis, C. Geoffrey; Goldstein, Joseph L.; Südhof, Thomas C.; Anderson, Richard G W; Russell, David W.; Brown, Michael S.

In: Nature, Vol. 326, No. 6115, 1987, p. 760-765.

Research output: Contribution to journalArticle

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