ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer

Bital Savir-Baruch; Kevin P. Banks; Jonathan E. McConathy; Olga P. Molchanova-Cook; Ephraim E. Parent; Amol Takalkar; Mark Tulchinsky; Jian Q. Yu; Rathan Subramaniam; David M. Schuster

doi:10.1097/RLU.0000000000002310

ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer

Bital Savir-Baruch, Kevin P. Banks, Jonathan E. McConathy, Olga P. Molchanova-Cook, Ephraim E. Parent, Amol Takalkar, Mark Tulchinsky, Jian Q. Yu, Rathan Subramaniam, David M. Schuster

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The American College of Radiology (ACR) and American College of Nuclear Medicine (ACNM) collaborated to develop a clinical practice document for the performance of fluciclovine positron-emission tomography (PET) / computed tomography (CT) in the evaluation of patients with suspected prostate cancer recurrence based on the elevation of prostate-specific antigen (PSA) level (biochemical recurrence) after prior therapy. Prostate cancer is the third leading cause of cancer death in the United States. Up to 50% of patients diagnosed with prostate cancer will develop biochemical failure after initial therapy. The differentiation of local from extraprostatic recurrence plays a critical role in patient management. The use of functional imaging targeting features of cancer metabolism has proven highly useful in this regard. Amino acid transport is upregulated in prostate cancer. Fluciclovine (anti-1-Amino-3-F-18-fluorocyclobutane-1-carboxylic acid, FACBC, Axumin™) is an artificial amino acid PET tracer which demonstrates utility in the diagnosis of recurrent prostate cancer with significant added value to conventional imaging.

Original language	English (US)
Pages (from-to)	909-917
Number of pages	9
Journal	Clinical nuclear medicine
Volume	43
Issue number	12
DOIs	https://doi.org/10.1097/RLU.0000000000002310
State	Published - Dec 1 2018

Keywords

18F-fluciclovine
FACBC
PET/CT
amino acid
axumin
prostate cancer

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/RLU.0000000000002310

Cite this

Savir-Baruch, B., Banks, K. P., McConathy, J. E., Molchanova-Cook, O. P., Parent, E. E., Takalkar, A., Tulchinsky, M., Yu, J. Q., Subramaniam, R., & Schuster, D. M. (2018). ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer. Clinical nuclear medicine, 43(12), 909-917. https://doi.org/10.1097/RLU.0000000000002310

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title = "ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer",

abstract = "The American College of Radiology (ACR) and American College of Nuclear Medicine (ACNM) collaborated to develop a clinical practice document for the performance of fluciclovine positron-emission tomography (PET) / computed tomography (CT) in the evaluation of patients with suspected prostate cancer recurrence based on the elevation of prostate-specific antigen (PSA) level (biochemical recurrence) after prior therapy. Prostate cancer is the third leading cause of cancer death in the United States. Up to 50% of patients diagnosed with prostate cancer will develop biochemical failure after initial therapy. The differentiation of local from extraprostatic recurrence plays a critical role in patient management. The use of functional imaging targeting features of cancer metabolism has proven highly useful in this regard. Amino acid transport is upregulated in prostate cancer. Fluciclovine (anti-1-Amino-3-F-18-fluorocyclobutane-1-carboxylic acid, FACBC, Axumin{\texttrademark}) is an artificial amino acid PET tracer which demonstrates utility in the diagnosis of recurrent prostate cancer with significant added value to conventional imaging.",

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AU - Yu, Jian Q.

AU - Subramaniam, Rathan

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ACR-ACNM Practice Parameter for the Performance of Fluorine-18 Fluciclovine-PET/CT for Recurrent Prostate Cancer

Abstract

Keywords

ASJC Scopus subject areas

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