ACTH1-39 inputs to mesocorticolimbic dopaminergic neurons

Light and electron microscopic examination

Chang Lin Liang, Gerald P. Kozlowski, Shirley A. Joseph, Dwight C. German

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Single- and double-labeling immunocytochemical staining procedures were used to examine the relationship between adrenocorticotropin (ACTH)-containing nerve terminals and dopaminergic (DA) neurons in the rat midbrain, using both light and electron microscopy. At the light microscopic level, ACTH neuronal processes were found largely in restricted regions occupied by the mesolimbic and mesocortical DA neurons. At the electron microscopic level, in the central linear nucleus, ACTH axon terminals made symmetric and asymmetric synaptic contacts with DA dendrites, as well as appositions with unlabeled axon terminals which, in turn, synapsed upon DA dendrites. These data suggest that ACTH functions as a neurotransmitter/neuromodulator in the brain, and such ACTH-DA synapses may be important for stress-induced changes in mesocorticolimbic DA neuronal activity.

Original languageEnglish (US)
Pages (from-to)79-83
Number of pages5
JournalNeuroscience Letters
Volume146
Issue number1
DOIs
StatePublished - Oct 26 1992

Fingerprint

Dopaminergic Neurons
Adrenocorticotropic Hormone
Electrons
Light
Presynaptic Terminals
Dendrites
Neurotransmitter Agents
Mesencephalon
Synapses
Electron Microscopy
Staining and Labeling
Brain

Keywords

  • Adrenocorticotropin
  • Immunocytochemistry
  • Rat
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

ACTH1-39 inputs to mesocorticolimbic dopaminergic neurons : Light and electron microscopic examination. / Liang, Chang Lin; Kozlowski, Gerald P.; Joseph, Shirley A.; German, Dwight C.

In: Neuroscience Letters, Vol. 146, No. 1, 26.10.1992, p. 79-83.

Research output: Contribution to journalArticle

Liang, Chang Lin ; Kozlowski, Gerald P. ; Joseph, Shirley A. ; German, Dwight C. / ACTH1-39 inputs to mesocorticolimbic dopaminergic neurons : Light and electron microscopic examination. In: Neuroscience Letters. 1992 ; Vol. 146, No. 1. pp. 79-83.
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