Abstract
We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.
Original language | English (US) |
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Pages (from-to) | 187-194 |
Number of pages | 8 |
Journal | Psychiatry research |
Volume | 24 |
Issue number | 2 |
DOIs | |
State | Published - May 1988 |
Keywords
- 5-hydroxyindoleacetic acid
- Cerebrospinal fluid
- normal volunteers
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry