Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid

Alec Roy, Bryon Adinoff, Markku Linnoila

Research output: Contribution to journalArticle

141 Scopus citations

Abstract

We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalPsychiatry research
Volume24
Issue number2
DOIs
StatePublished - May 1988

Keywords

  • 5-hydroxyindoleacetic acid
  • Cerebrospinal fluid
  • normal volunteers

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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