Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid

Alec Roy; Bryon Adinoff; Markku Linnoila

doi:10.1016/0165-1781(88)90061-3

Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid

Alec Roy, Bryon Adinoff, Markku Linnoila

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.

Original language	English (US)
Pages (from-to)	187-194
Number of pages	8
Journal	Psychiatry research
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(88)90061-3
State	Published - May 1988

Keywords

5-hydroxyindoleacetic acid
Cerebrospinal fluid
normal volunteers

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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AU - Adinoff, Bryon

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N2 - We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.

AB - We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.

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KW - Cerebrospinal fluid

KW - normal volunteers

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Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid

Abstract

Keywords

ASJC Scopus subject areas

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