Abstract
We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-194 |
| Number of pages | 8 |
| Journal | Psychiatry research |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 1988 |
Keywords
- 5-hydroxyindoleacetic acid
- Cerebrospinal fluid
- normal volunteers
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
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Roy, A., Adinoff, B., & Linnoila, M. (1988). Acting out hostility in normal volunteers: Negative correlation with levels of 5HIAA in cerebrospinal fluid. Psychiatry research, 24(2), 187-194. https://doi.org/10.1016/0165-1781(88)90061-3