Abstract
We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 187-194 |
| Number of pages | 8 |
| Journal | Psychiatry Research |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1988 |
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Keywords
- 5-hydroxyindoleacetic acid
- Cerebrospinal fluid
- normal volunteers
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Psychology(all)
Cite this
Acting out hostility in normal volunteers : Negative correlation with levels of 5HIAA in cerebrospinal fluid. / Roy, Alec; Adinoff, Bryon; Linnoila, Markku.
In: Psychiatry Research, Vol. 24, No. 2, 1988, p. 187-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acting out hostility in normal volunteers
T2 - Negative correlation with levels of 5HIAA in cerebrospinal fluid
AU - Roy, Alec
AU - Adinoff, Bryon
AU - Linnoila, Markku
PY - 1988
Y1 - 1988
N2 - We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.
AB - We examined relationships in normal volunteers between cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5HIAA) and scores on the Hostility and Direction of Hostility Questionnaire. There was a significant negative correlation between CSF 5HIAA levels and scores on the "urge to act out hostility" subscale, as well as a similar nonsignificant trend with CSF levels of homovanillic acid. These results suggest that among normal individuals reduced central serotonergic tone may be associated with impaired impulse control.
KW - 5-hydroxyindoleacetic acid
KW - Cerebrospinal fluid
KW - normal volunteers
UR - http://www.scopus.com/inward/record.url?scp=0023923411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023923411&partnerID=8YFLogxK
U2 - 10.1016/0165-1781(88)90061-3
DO - 10.1016/0165-1781(88)90061-3
M3 - Article
C2 - 2457227
AN - SCOPUS:0023923411
VL - 24
SP - 187
EP - 194
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 2
ER -