Actions of human telomerase beyond telomeres

Yusheng Cong, Jerry W. Shay

Research output: Contribution to journalReview articlepeer-review

181 Scopus citations

Abstract

Telomerase has fundamental roles in bypassing cellular aging and in cancer progression by maintaining telomere homeostasis and integrity. However, recent studies have led some investigators to suggest novel biochemical properties of telomerase in several essential cell signaling pathways without apparent involvement of its well established function in telomere maintenance. These observations may further enhance our understanding of the molecular actions of telomerase in aging and cancer. This review will provide an update on the extracurricular activities of telomerase in apoptosis, DNA repair, stem cell function, and in the regulation of gene expression.

Original languageEnglish (US)
Pages (from-to)725-732
Number of pages8
JournalCell Research
Volume18
Issue number7
DOIs
StatePublished - Jul 2008

Keywords

  • Aging
  • Apoptosis
  • Cancer
  • DNA damage response
  • Immortalization

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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