Abstract
Background: Activated RhoA binds to the PH domain of its own GEF, PDZRhoGEF. Results: Activated RhoA binds to all Lbc RhoGEFs and provides positive feedback regulation to these regulators. Conclusion: Allosteric binding of activated RhoA to its own regulators facilitates other regulatory stimuli. Significance: This autoregulatory mechanism could mediate robust localized signaling and may represent a general paradigm for regulation of other monomeric GTPases.
Original language | English (US) |
---|---|
Pages (from-to) | 11325-11333 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 16 |
DOIs | |
State | Published - Apr 19 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology