Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

Frank Medina, Angela M. Carter, Olugbenga Dada, Stephen Gutowski, Jana Hadas, Zhe Chen, Paul C. Sternweis

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: Activated RhoA binds to the PH domain of its own GEF, PDZRhoGEF. Results: Activated RhoA binds to all Lbc RhoGEFs and provides positive feedback regulation to these regulators. Conclusion: Allosteric binding of activated RhoA to its own regulators facilitates other regulatory stimuli. Significance: This autoregulatory mechanism could mediate robust localized signaling and may represent a general paradigm for regulation of other monomeric GTPases.

Original languageEnglish (US)
Pages (from-to)11325-11333
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
StatePublished - Apr 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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