Activation and interaction of CD44 and hyaluronan in immunological systems

Mark H. Siegelman, Heather C. DeGrendele, Pila Estess

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Adhesive interactions between receptors on vascular endothelial cells (EC) and circulating leukocytes are pivotal in regulating leukocyte extravasation. Although primary adhesion of lymphocytes to EC has been primarily attributed to the selecting family of receptors, CD44 can also mediate tiffs function when activated to bind its ligand hyaluronan (HA). Triggering through the T cell receptor induces activated CD44 and CD44 dependent primary adhesion in both human and mouse lymphocytes, and the interaction can mediate the extravasation of activated T cells into an inflamed site. Lymphocytes capable of CD44/HA dependent primary adhesion are found in peripheral blood of some rheumatologic patients, and their presence is associated with concurrent symptomatic or active disease. Thus, circulating T cells bearing activated CD44 may represent a pathogenically important subpopulation of activated cells that is elevated under conditions of chronic inflammation. Together, these data add to the selecting and immunoglobulin gene families a new receptor/ ligand pair and further our understanding of their potential physiological role; i.e., antigen-specific T cell activation together with local vascular inflammation permits the CD44/HA interaction and subsequent T cell extravasation.

Original languageEnglish (US)
Pages (from-to)315-321
Number of pages7
JournalJournal of Leukocyte Biology
Volume66
Issue number2
StatePublished - 1999

Fingerprint

Hyaluronic Acid
Lymphocytes
T-Lymphocytes
Leukocytes
Endothelial Cells
CD27 Antigens
Ligands
Inflammation
Immunoglobulin Genes
T-Cell Antigen Receptor
Adhesives
Blood Vessels

Keywords

  • Adhesion
  • Arthritis
  • Hyaluronate
  • Inflammation
  • Systemic lupus erythematosis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Siegelman, M. H., DeGrendele, H. C., & Estess, P. (1999). Activation and interaction of CD44 and hyaluronan in immunological systems. Journal of Leukocyte Biology, 66(2), 315-321.

Activation and interaction of CD44 and hyaluronan in immunological systems. / Siegelman, Mark H.; DeGrendele, Heather C.; Estess, Pila.

In: Journal of Leukocyte Biology, Vol. 66, No. 2, 1999, p. 315-321.

Research output: Contribution to journalArticle

Siegelman, MH, DeGrendele, HC & Estess, P 1999, 'Activation and interaction of CD44 and hyaluronan in immunological systems', Journal of Leukocyte Biology, vol. 66, no. 2, pp. 315-321.
Siegelman, Mark H. ; DeGrendele, Heather C. ; Estess, Pila. / Activation and interaction of CD44 and hyaluronan in immunological systems. In: Journal of Leukocyte Biology. 1999 ; Vol. 66, No. 2. pp. 315-321.
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