Activation of murine epidermal γδ T cells through surface 2B4

G. Schuhmachers, K. Ariizumi, P. A. Mathew, M. Bennett, V. Kumar, A. Takashima

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Dendritic epidermal T cell (DETC) are γδ T cell that normally reside in murine skin. They express on their surface the 2B4 molecule, a 66-KDa glycoprotein of the immunoglobulin gene superfamily thought to be associated with anti-tumor cytotoxicity by natural by killer and lymphokine-activated killer cells. Here, we show that ligation of surface 2B4 transduces cell activation signals in DETC. Treatment with anti-2B4 monoclonal antibodies triggers the secretion of interferon-γ and interleukin-2 by DETC lines, induces proliferation of resting DECT lines, amplifies anti-CD3-dependent proliferation of DETC freshly isolated from mouse skin; and up-regulates egr-1 and c-fos mRNA expression. These results indicate a unique pathway for DETC activation.

Original languageEnglish (US)
Pages (from-to)1117-1120
Number of pages4
JournalEuropean Journal of Immunology
Volume25
Issue number4
StatePublished - 1995

Fingerprint

T-Lymphocytes
Lymphokine-Activated Killer Cells
Immunoglobulin Genes
Skin
Interferons
Interleukin-2
Ligation
Glycoproteins
Up-Regulation
Monoclonal Antibodies
Cell Line
Messenger RNA
Neoplasms

Keywords

  • 2B4
  • Dendritic epidermal T cells
  • Signalling

ASJC Scopus subject areas

  • Immunology

Cite this

Schuhmachers, G., Ariizumi, K., Mathew, P. A., Bennett, M., Kumar, V., & Takashima, A. (1995). Activation of murine epidermal γδ T cells through surface 2B4. European Journal of Immunology, 25(4), 1117-1120.

Activation of murine epidermal γδ T cells through surface 2B4. / Schuhmachers, G.; Ariizumi, K.; Mathew, P. A.; Bennett, M.; Kumar, V.; Takashima, A.

In: European Journal of Immunology, Vol. 25, No. 4, 1995, p. 1117-1120.

Research output: Contribution to journalArticle

Schuhmachers, G, Ariizumi, K, Mathew, PA, Bennett, M, Kumar, V & Takashima, A 1995, 'Activation of murine epidermal γδ T cells through surface 2B4', European Journal of Immunology, vol. 25, no. 4, pp. 1117-1120.
Schuhmachers G, Ariizumi K, Mathew PA, Bennett M, Kumar V, Takashima A. Activation of murine epidermal γδ T cells through surface 2B4. European Journal of Immunology. 1995;25(4):1117-1120.
Schuhmachers, G. ; Ariizumi, K. ; Mathew, P. A. ; Bennett, M. ; Kumar, V. ; Takashima, A. / Activation of murine epidermal γδ T cells through surface 2B4. In: European Journal of Immunology. 1995 ; Vol. 25, No. 4. pp. 1117-1120.
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